Atherosclerotic cardiovascular disease (ASCVD) the underlying cause of most cardiovascular diseases and is an increasing threat to global health. Although the prognosis of ASCVD has been improved by medicine therapy and surgical intervention, the mortality rate of ASCVD is still increasing, hence there is an urgent need to probe into the molecular mechanism of ASCVD and seek new therapeutic strategies.
ASCVD is a chronic inflammatory disease caused by the synergy of genetic and environmental factors. Epigenetics, a discipline to explore the interaction between genetics and environment, has increasingly been applied to ASCVD research in recent years. Many studies have demonstrated that multiple epigenetic factors, including DNA methylation, noncoding RNA and histone modifications, are involved in the occurrence and development of ASCVD, by affecting the regulation and function of monocytes, vascular endothelial cells and vascular smooth muscle cells. Further exploration of epigenetic regulatory mechanisms may provide novel directions for the diagnosis and treatment of ASCVD.
As epigenetic research progresses, the understanding of the molecular mechanisms underlying ASCVD pathophysiology becomes more comprehensive. While some of the roles that the epigenetic factors play in ASCVD have been elucidated, there are still conundrums that remain to be tackled. For instance, the question of whether the poor reproducibility of epigenome wide association studies (EWAS) are related to the labile pathologic status of ASCVD remains unresolved, and the relevance of epigenetic factors is not fully illuminated. In this research topic, we are going to summarize the current advances on the epigenetic-related research of ASCVD, ranging from multiple-omics to studies of molecular mechanisms and clinical data interpretation.
Subtopics of interest include, but are not limited to:
1) Epigenetic biomarkers for the diagnosis or prognosis of ASCVD, such as DNA methylation, RNA modification, noncoding RNAs, histone modification, etc.
2) Diagnostic and prognostic model of ASCVD based on clinical data or experimental data.
3) Functional roles of noncoding RNAs and noncoding-RNA-related regulatory pathways in ASCVD.
4) Interactions among epigenetic factors, environment, and transcriptional factors in ASCVD.
5) Studies using “omics” approaches to investigate ASCVD.
6) Novel epigenetics-related experimental methods, and evaluations of epigenetics-related detection methods and platforms.
Original epigenetic research, review articles and methodology articles on the latest development of ASCVD are welcomed in this research topic.
Atherosclerotic cardiovascular disease (ASCVD) the underlying cause of most cardiovascular diseases and is an increasing threat to global health. Although the prognosis of ASCVD has been improved by medicine therapy and surgical intervention, the mortality rate of ASCVD is still increasing, hence there is an urgent need to probe into the molecular mechanism of ASCVD and seek new therapeutic strategies.
ASCVD is a chronic inflammatory disease caused by the synergy of genetic and environmental factors. Epigenetics, a discipline to explore the interaction between genetics and environment, has increasingly been applied to ASCVD research in recent years. Many studies have demonstrated that multiple epigenetic factors, including DNA methylation, noncoding RNA and histone modifications, are involved in the occurrence and development of ASCVD, by affecting the regulation and function of monocytes, vascular endothelial cells and vascular smooth muscle cells. Further exploration of epigenetic regulatory mechanisms may provide novel directions for the diagnosis and treatment of ASCVD.
As epigenetic research progresses, the understanding of the molecular mechanisms underlying ASCVD pathophysiology becomes more comprehensive. While some of the roles that the epigenetic factors play in ASCVD have been elucidated, there are still conundrums that remain to be tackled. For instance, the question of whether the poor reproducibility of epigenome wide association studies (EWAS) are related to the labile pathologic status of ASCVD remains unresolved, and the relevance of epigenetic factors is not fully illuminated. In this research topic, we are going to summarize the current advances on the epigenetic-related research of ASCVD, ranging from multiple-omics to studies of molecular mechanisms and clinical data interpretation.
Subtopics of interest include, but are not limited to:
1) Epigenetic biomarkers for the diagnosis or prognosis of ASCVD, such as DNA methylation, RNA modification, noncoding RNAs, histone modification, etc.
2) Diagnostic and prognostic model of ASCVD based on clinical data or experimental data.
3) Functional roles of noncoding RNAs and noncoding-RNA-related regulatory pathways in ASCVD.
4) Interactions among epigenetic factors, environment, and transcriptional factors in ASCVD.
5) Studies using “omics” approaches to investigate ASCVD.
6) Novel epigenetics-related experimental methods, and evaluations of epigenetics-related detection methods and platforms.
Original epigenetic research, review articles and methodology articles on the latest development of ASCVD are welcomed in this research topic.