Therapeutic Modulators Inhibiting Neuromuscular and Motor Neuron Degeneration

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Background

A neurological disorder is a nervous system disorder that causes structural and biochemical abnormalities in the brain, spinal cord, or other nerves, resulting in a variety of symptoms such as motor and cognitive dysfunctions, paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain, and altered levels of consciousness. Motor neuron degeneration (MND) is characterised by lesions in both the Upper Motor Neuron (UMN) and the Lower Motor Neuron (LMN). When the lower motor neurons are unable to receive signals from the upper motor neurons, muscle rigidity (spasticity) and hyperactive reflexes might occur. Voluntary movements may become slow and challenging as a result of this. Individuals suffering from MNDs may lose the capacity to walk or regulate other movements over time. There are about 600 neural system diseases, including well-known ones such as Parkinson disease, Huntington's Disease, intracerebral haemorrhage, epilepsy, and stroke, as well as well-known ones including front temporal dementia, ALS, Multiple sclerosis, and Autism. A thorough understanding of the varying expression of numerous signalling pathways, genetic dysfunctions, apoptosis, oxidative stress, neuroinflammation, demyelination, and neurotransmitter imbalance may aid in the development of novel therapeutic approaches for these severe neurological illnesses.



The goal of this issue is to present a comprehensive and up-to-date overview of the signalling pathway of motor neuron and neuromuscular degenerative diseases and how target modulators can result in clinical and molecular observations that may lead to novel therapeutic insights for disease treatment.



Theme focusing on:

Signal transductions and therapeutic moieties in the prevention of Motor Neuron Diseases (Multiple sclerosis and Amyotrophic lateral sclerosis), Alzheimer’s Disease, Autism, Brain Hemorrhage, Traumatic brain injury, cerebral hemorrhage, Huntington’s disease, Parkinson’s disease.

Theme Targets:

Neurogenesis, ERK, c-JNK, p38MAPK, sonic hedgehog (shh), SIRT-1, JAK-STAT, nrf2/HO-1, GLP-1/IGF-1, PPAR-ϒ, PI3K/AKT, mTOR, and Neuronal mitochondrial (CoQ10, ETC)-Complexes.

Keywords: Motor Neuron Disorders, Neuromuscular diseases, signal transduction, neurotoxins, phytoconstituents, remyelination

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