With the rapid development of metagenomic high-throughput sequencing technology, more and more evidence of the association between microbiome and human diseases has been revealed. Microbiota display critical effects on host nutrition, immunity, metabolism, and diseases. The epithelial mucosae are important barriers and play essential roles in defense against pathogenic microbiota in the epithelium of the human oral cavity, esophagus, stomach, intestine, colorectum and so on. However, the causality of microbiota in host mucosa development, dysfunction and diseases remain a challenge.
This Research Topic aims to better understand the relationship, causality and molecular mechanism of microbiota in the development of host mucosa, the dysfunction of mucosal barriers, and the process of human mucosa diseases.
In this topic, we welcome original articles of basic, translational research, literature reviews, mini-reviews, meta-analysis, method papers and case reports in the following five scopes.
1. The crosstalk between microbiota and the development, structure, barrier function of human epithelial mucosa.
2. The interaction of microbiota and human nutrition, immunity, metabolism, and mucosa diseases, including cancer immunotherapy.
3. Microbiota-mediated epigenetic regulation in human mucosa disease.
4. The microbial biofilm formation and its function in mucosa diseases.
5. Novel methods or models about microbiota studies in vitro and in vivo.
With the rapid development of metagenomic high-throughput sequencing technology, more and more evidence of the association between microbiome and human diseases has been revealed. Microbiota display critical effects on host nutrition, immunity, metabolism, and diseases. The epithelial mucosae are important barriers and play essential roles in defense against pathogenic microbiota in the epithelium of the human oral cavity, esophagus, stomach, intestine, colorectum and so on. However, the causality of microbiota in host mucosa development, dysfunction and diseases remain a challenge.
This Research Topic aims to better understand the relationship, causality and molecular mechanism of microbiota in the development of host mucosa, the dysfunction of mucosal barriers, and the process of human mucosa diseases.
In this topic, we welcome original articles of basic, translational research, literature reviews, mini-reviews, meta-analysis, method papers and case reports in the following five scopes.
1. The crosstalk between microbiota and the development, structure, barrier function of human epithelial mucosa.
2. The interaction of microbiota and human nutrition, immunity, metabolism, and mucosa diseases, including cancer immunotherapy.
3. Microbiota-mediated epigenetic regulation in human mucosa disease.
4. The microbial biofilm formation and its function in mucosa diseases.
5. Novel methods or models about microbiota studies in vitro and in vivo.