T cells play a crucial role in the host's defense against pathogens and maintain tolerance with normal microbiota in the body. However, sometimes exogenous triggers may disrupt T cell homeostasis, which breaks down T cell tolerance and induces T cell exhaustion leading to autoimmunity, chronic infections, and cancers. Recent research advances in immunology have introduced new technologies to investigate T cell regulation at the single-cell level and on an omics scale, including genome-wide association studies, epigenomes (DNA methylation, histone modification, and microRNA) profile, and transcriptome in T cells. The integration of this information will provide new insights into the mechanisms of T cell dysregulation under pathogenic conditions. Furthermore, this information may also help to design novel therapeutics or develop biomarkers for prediction, diagnosis, prognosis, and treatment response.
Here, we invite researchers to contribute original research articles as well as review articles that use the omics approach to study T cell dysregulation and to develop therapeutic interventions. We are particularly interested in articles analyzing T cells with different statuses (naïve/effector/memory) and linking these results with disease status and prognosis. We welcome manuscripts from, but not limited to, the following subtopics:
1, Genome-wide association studies in autoimmunity, chronic infection, and cancer on T cells
2, Epigenetic modifications (DNA methylation, histone modification, and microRNA) in T cell development and activation
3, Environmental triggers and epigenetic changes in T cell dysregulation
4, Single-cell transcriptome sequencing on pathogenic T cells from various human diseases
5, Genetic and epigenetic biomarkers on T cells for diseases
6, Genetic, epigenetic, biologics, and T cell-based therapies for autoimmune diseases, chronic infection, and cancers
T cells play a crucial role in the host's defense against pathogens and maintain tolerance with normal microbiota in the body. However, sometimes exogenous triggers may disrupt T cell homeostasis, which breaks down T cell tolerance and induces T cell exhaustion leading to autoimmunity, chronic infections, and cancers. Recent research advances in immunology have introduced new technologies to investigate T cell regulation at the single-cell level and on an omics scale, including genome-wide association studies, epigenomes (DNA methylation, histone modification, and microRNA) profile, and transcriptome in T cells. The integration of this information will provide new insights into the mechanisms of T cell dysregulation under pathogenic conditions. Furthermore, this information may also help to design novel therapeutics or develop biomarkers for prediction, diagnosis, prognosis, and treatment response.
Here, we invite researchers to contribute original research articles as well as review articles that use the omics approach to study T cell dysregulation and to develop therapeutic interventions. We are particularly interested in articles analyzing T cells with different statuses (naïve/effector/memory) and linking these results with disease status and prognosis. We welcome manuscripts from, but not limited to, the following subtopics:
1, Genome-wide association studies in autoimmunity, chronic infection, and cancer on T cells
2, Epigenetic modifications (DNA methylation, histone modification, and microRNA) in T cell development and activation
3, Environmental triggers and epigenetic changes in T cell dysregulation
4, Single-cell transcriptome sequencing on pathogenic T cells from various human diseases
5, Genetic and epigenetic biomarkers on T cells for diseases
6, Genetic, epigenetic, biologics, and T cell-based therapies for autoimmune diseases, chronic infection, and cancers