Diabetes is a worldwide epidemic. Associated neuropathy is one of the most common and troublesome complications of diabetes, with increasing morbidity and mortality.
Diabetic peripheral neuropathy is a disease of demyelination in the peripheral nerves. However, the damage to the nervous system in diabetes is not confined to just “peripheral” nerves. Pathologically, hyperglycaemia and associated metabolic disorders are extensive and their induced injury occurs in multiple systems, including vasculature, nerves, and the brain. There is plenty of evidence indicating that the damage to peripheral neuropathy in diabetes is reflected in the central nervous system, which can be used as an early diagnostic marker. Hence diabetic neuropathy is a combined disorder of central and peripheral nerve damage. Uncovering the interactions between the vasculature, peripheral, and central nervous systems during the development of diabetic neuropathy will help us discover early biomarkers of diabetic neuropathy and innovative interventional targets.
In this Research Topic, we aim to explore early biomarkers of diabetic neuropathy. We seek innovative interventional treatment targets through in-depth study of the clinical features, pathogenesis, and molecular mechanisms of diabetic neuropathy. In particular, the interactions between the vasculature, central nervous system, and peripheral nervous system, during the development of diabetic neuropathy.
We welcome submissions of clinical and basic research that advance diabetic neuropathy investigations, including but not limited to, the below subtopics:
• Mechanisms of diabetes associated neuropathy
• Clinical consequences or hazard of diabetic neuropathy on cognitive function and quality of life
• The interactions between central and peripheral nerves during the development of diabetic neuropathy
• Cerebral ischemic reperfusion damage in diabetes and the role of cerebral blood flow (CBF) in central nerve neuropathy
• The crosstalk between vasculature and nervous systems during the development of diabetic neuropathy
• Investigation and evaluation of the potential treatments and prevention of diabetic neuropathy
• Determination or assessment of early diagnostic biomarkers for diabetic neuropathy
Diabetes is a worldwide epidemic. Associated neuropathy is one of the most common and troublesome complications of diabetes, with increasing morbidity and mortality.
Diabetic peripheral neuropathy is a disease of demyelination in the peripheral nerves. However, the damage to the nervous system in diabetes is not confined to just “peripheral” nerves. Pathologically, hyperglycaemia and associated metabolic disorders are extensive and their induced injury occurs in multiple systems, including vasculature, nerves, and the brain. There is plenty of evidence indicating that the damage to peripheral neuropathy in diabetes is reflected in the central nervous system, which can be used as an early diagnostic marker. Hence diabetic neuropathy is a combined disorder of central and peripheral nerve damage. Uncovering the interactions between the vasculature, peripheral, and central nervous systems during the development of diabetic neuropathy will help us discover early biomarkers of diabetic neuropathy and innovative interventional targets.
In this Research Topic, we aim to explore early biomarkers of diabetic neuropathy. We seek innovative interventional treatment targets through in-depth study of the clinical features, pathogenesis, and molecular mechanisms of diabetic neuropathy. In particular, the interactions between the vasculature, central nervous system, and peripheral nervous system, during the development of diabetic neuropathy.
We welcome submissions of clinical and basic research that advance diabetic neuropathy investigations, including but not limited to, the below subtopics:
• Mechanisms of diabetes associated neuropathy
• Clinical consequences or hazard of diabetic neuropathy on cognitive function and quality of life
• The interactions between central and peripheral nerves during the development of diabetic neuropathy
• Cerebral ischemic reperfusion damage in diabetes and the role of cerebral blood flow (CBF) in central nerve neuropathy
• The crosstalk between vasculature and nervous systems during the development of diabetic neuropathy
• Investigation and evaluation of the potential treatments and prevention of diabetic neuropathy
• Determination or assessment of early diagnostic biomarkers for diabetic neuropathy