The main scope of this research topic is to create a collection of studies discussing the expression changes and functionality in coding and non-coding RNAs during infection with veterinary infectious diseases. We welcome submissions of original research papers, reviews, and perspectives on the themes below (but not limited to):
- Profiling of RNAs (mRNA, small and long non-coding RNAs) during infection with animal infectious diseases.
- mRNA-microRNA interaction during infection with animal infectious diseases.
- Various involvment of RNAs in different aspects of disease pathobiology.
- Biomarker-oriented studies targeting coding or non-coding RNAs
- Genetics of small non-coding RNAs, and relation to animal infectious disease mechanisms
- Studies on therapeutic potential of RNAs in controlling or preventing animal infectious diseases
Infection with infectious diseases remains one of the big challenges for both animal and public health. A part from pathogens themselves, infection of animals with infectious agents is known to trigger expression changes in various elements of the host response, where coding and non-coding genes are central components. Indeed, most of the studies on infection dynamics of veterinary infectious diseases have focused on infection-driven changes in protein expression, underutilizing the role of coding and non-coding in these scenarios.
While coding RNAs are genes that are translated to functional proteins, non-coding RNAs (including their long and small varieties) are not translated into protein, but rather play a regulatory role mostly by binding to coding genes, which results in changes in protein expression.
In veterinary medicine, small non-coding RNAs (sncRNAs) have received less research attention if compared to the human medicine, where some molecules have progressed to market product. SncRNAs include variable classes that differ in terms of size, biogenesis and function namely microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs) and PIWI-interacting protein (piRNAs). Profiling RNAs in animal secretions, excretions or in cells will open doors for utilizing them as biomarkers that could pinpoint the diseases or tell about its prognosis. In addition, detailed understanding of how coding and non-coding RNAs interact together or with the pathogen during an infection event make them potential therapeutic targets and open the possibilities to use them as tools to generate disease-resistant livestock.
The main scope of this research topic is to create a collection of studies discussing the expression changes and functionality in coding and non-coding RNAs during infection with veterinary infectious diseases. We welcome submissions of original research papers, reviews, and perspectives on the themes below (but not limited to):
- Profiling of RNAs (mRNA, small and long non-coding RNAs) during infection with animal infectious diseases.
- mRNA-microRNA interaction during infection with animal infectious diseases.
- Various involvment of RNAs in different aspects of disease pathobiology.
- Biomarker-oriented studies targeting coding or non-coding RNAs
- Genetics of small non-coding RNAs, and relation to animal infectious disease mechanisms
- Studies on therapeutic potential of RNAs in controlling or preventing animal infectious diseases
Infection with infectious diseases remains one of the big challenges for both animal and public health. A part from pathogens themselves, infection of animals with infectious agents is known to trigger expression changes in various elements of the host response, where coding and non-coding genes are central components. Indeed, most of the studies on infection dynamics of veterinary infectious diseases have focused on infection-driven changes in protein expression, underutilizing the role of coding and non-coding in these scenarios.
While coding RNAs are genes that are translated to functional proteins, non-coding RNAs (including their long and small varieties) are not translated into protein, but rather play a regulatory role mostly by binding to coding genes, which results in changes in protein expression.
In veterinary medicine, small non-coding RNAs (sncRNAs) have received less research attention if compared to the human medicine, where some molecules have progressed to market product. SncRNAs include variable classes that differ in terms of size, biogenesis and function namely microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs) and PIWI-interacting protein (piRNAs). Profiling RNAs in animal secretions, excretions or in cells will open doors for utilizing them as biomarkers that could pinpoint the diseases or tell about its prognosis. In addition, detailed understanding of how coding and non-coding RNAs interact together or with the pathogen during an infection event make them potential therapeutic targets and open the possibilities to use them as tools to generate disease-resistant livestock.