The surging obesity epidemic continues to gain momentum and as of 2016 resulting in approximately 650 million people suffering from the disease. Cancer and specifically breast cancer continues to be equally an prevalent disease. According to the World Health Organisation, in 2020, there were 2.3 million women diagnosed with breast cancer resulting in 685 000 deaths globally. These two hugely prevalent disease pose great challenges to public health and consequently to public health services. Nevertheless, obesity has long been know as a leading cause of cancer. Therefore, understanding this relationship could be key in effective obesity management and cancer prevention.
In postmenopausal women, whose who are obese can have a 20 to 40% increases risk of developing breast cancer. As breast cancer is the second leading cause of cancer related deaths in women, understanding the significance of obesity as a prognostic impact factor on the disease is a key research area. Nonetheless, the possible mechanisms underlying the link between obesity and increased cancer risk are yet to be fully explained. The impacts of obesity on human physiology include dysregulation of insulin, insulin-like growth factor, adipokines and inflammatory factors, all of which could be implicated in multiple diseases including cancer.
This Research Topic aims to highlight the link between obesity and breast cancer and to what extent we can understand the relationship and the potential for effective interventions. We will accept both original research and reviews on the following, but not limited to:
• Cohort and observational studies on the link between obesity and breast cancer
• The impact of obesity on physiology including inflammation, sex hormones, adipokines, insulin dysregulation and insulin-like growth factor.
• How the above factors impact cancer onset and progression including cell proliferation, angiogenesis n, oncogene activation and immune cell dysfunction
• How can physical and nutritional interventions to obesity lessen breast cancer risk
• How obesity can influence the efficacy of breast cancer therapies
• Prospective interventions to break the Obesity-Cancer link
The surging obesity epidemic continues to gain momentum and as of 2016 resulting in approximately 650 million people suffering from the disease. Cancer and specifically breast cancer continues to be equally an prevalent disease. According to the World Health Organisation, in 2020, there were 2.3 million women diagnosed with breast cancer resulting in 685 000 deaths globally. These two hugely prevalent disease pose great challenges to public health and consequently to public health services. Nevertheless, obesity has long been know as a leading cause of cancer. Therefore, understanding this relationship could be key in effective obesity management and cancer prevention.
In postmenopausal women, whose who are obese can have a 20 to 40% increases risk of developing breast cancer. As breast cancer is the second leading cause of cancer related deaths in women, understanding the significance of obesity as a prognostic impact factor on the disease is a key research area. Nonetheless, the possible mechanisms underlying the link between obesity and increased cancer risk are yet to be fully explained. The impacts of obesity on human physiology include dysregulation of insulin, insulin-like growth factor, adipokines and inflammatory factors, all of which could be implicated in multiple diseases including cancer.
This Research Topic aims to highlight the link between obesity and breast cancer and to what extent we can understand the relationship and the potential for effective interventions. We will accept both original research and reviews on the following, but not limited to:
• Cohort and observational studies on the link between obesity and breast cancer
• The impact of obesity on physiology including inflammation, sex hormones, adipokines, insulin dysregulation and insulin-like growth factor.
• How the above factors impact cancer onset and progression including cell proliferation, angiogenesis n, oncogene activation and immune cell dysfunction
• How can physical and nutritional interventions to obesity lessen breast cancer risk
• How obesity can influence the efficacy of breast cancer therapies
• Prospective interventions to break the Obesity-Cancer link
