Myocardial remodeling (MR) represents one of the main problems in cardiovascular diseases, with an impactful role in public health. Most guideline-recommended several classes of drugs (e.g. angiotensin-converting enzyme inhibitors, beta-blockers, and mineralocorticoid receptor antagonists), invasive procedures, and behavioral changes to counteract MR preventing progression to heart failure (HF). These approaches are predicted to be useful to reduce the mortality of patients. However, it is an ongoing challenge to prevent the adverse effects of MR. Despite advances of the last decades, effective therapeutic interventions remain elusive. Chronically, progressive cardiac dysfunction and increased mortality is not uncommon. Therefore, novel evidence-based approaches will open the way for promising agents targeting MR molecular substrates. The impact of these targeted interventions will hopefully alter the natural history of the disease in the near future.
This Research Topic aims to further contribute to the knowledge of new therapies that can prevent or benefit the progression of the MR. Authors are welcome to submit preclinical and clinical articles that focus on innovative pharmacological and surgical interventions, medical devices, and gene and cell therapies. There shall be a special focus on innovative, organ targeting interventions aiming to reduce the burden of myocardial effects. In addition to single target strategies, we specifically encourage submissions of manuscripts addressing multi-target approaches for therapy.
There shall be a special focus on innovative, organ targeting interventions aiming to reduce the burden of myocardial effects. In addition to single-target strategies, we specifically encourage submissions of manuscripts addressing multi-target approaches for therapy.
Myocardial remodeling (MR) represents one of the main problems in cardiovascular diseases, with an impactful role in public health. Most guideline-recommended several classes of drugs (e.g. angiotensin-converting enzyme inhibitors, beta-blockers, and mineralocorticoid receptor antagonists), invasive procedures, and behavioral changes to counteract MR preventing progression to heart failure (HF). These approaches are predicted to be useful to reduce the mortality of patients. However, it is an ongoing challenge to prevent the adverse effects of MR. Despite advances of the last decades, effective therapeutic interventions remain elusive. Chronically, progressive cardiac dysfunction and increased mortality is not uncommon. Therefore, novel evidence-based approaches will open the way for promising agents targeting MR molecular substrates. The impact of these targeted interventions will hopefully alter the natural history of the disease in the near future.
This Research Topic aims to further contribute to the knowledge of new therapies that can prevent or benefit the progression of the MR. Authors are welcome to submit preclinical and clinical articles that focus on innovative pharmacological and surgical interventions, medical devices, and gene and cell therapies. There shall be a special focus on innovative, organ targeting interventions aiming to reduce the burden of myocardial effects. In addition to single target strategies, we specifically encourage submissions of manuscripts addressing multi-target approaches for therapy.
There shall be a special focus on innovative, organ targeting interventions aiming to reduce the burden of myocardial effects. In addition to single-target strategies, we specifically encourage submissions of manuscripts addressing multi-target approaches for therapy.