Precision Medicine in Pediatrics

95K

views

224

authors

25

articles

Precision Medicine in Pediatrics

95K

views

224

authors

25

articles

Editors

4

Shanghai Children's Medical Center

Beijing Children’s Hospital, Capital Medical University

Brown University

Department of Medicine, Icahn School of Medicine at Mount Sinai

Impact

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In recent years, precision medicine has become increasingly indispensable. Based on big data, personalized medication through patients’ clinical symptoms and lifestyles can make treatment more effective and adverse reactions less, which is especially important in pediatrics. However, the disease spectrum of children is different from adults: the smaller the age, the more significant the difference. Therefore, while there are insufficient medicines for children, most drugs are used for adults with reduced doses. Moreover, children’s drug metabolism system, such as the liver, is not fully developed, and the biotransformation ability is insufficient, making the usual dosage of drugs show toxicity. Studies on children's pharmacogenomics, proteomics and metabolomics have recently provided new insights into pediatric precision medicine.

This research topic aims to understand better precision medicine in pediatrics, particularly the cutting-edge research on the pharmacological mechanism and pathogenesis. We welcome the following areas but are not limited to:

• Precision medicine in pediatrics
• Pathogenesis of pediatrics diseases
• Pediatric pharmacogenomics/proteomics/metabolomics
• Drug discovery and development
• Establishment of a pediatric precision medicine database

In recent years, precision medicine has become increasingly indispensable. Based on big data, personalized medication through patients’ clinical symptoms and lifestyles can make treatment more effective and adverse reactions less, which is especially important in pediatrics. However, the disease spectrum of children is different from adults: the smaller the age, the more significant the difference. Therefore, while there are insufficient medicines for children, most drugs are used for adults with reduced doses. Moreover, children’s drug metabolism system, such as the liver, is not fully developed, and the biotransformation ability is insufficient, making the usual dosage of drugs show toxicity. Studies on children's pharmacogenomics, proteomics and metabolomics have recently provided new insights into pediatric precision medicine.

This research topic aims to understand better precision medicine in pediatrics, particularly the cutting-edge research on the pharmacological mechanism and pathogenesis. We welcome the following areas but are not limited to:

• Precision medicine in pediatrics
• Pathogenesis of pediatrics diseases
• Pediatric pharmacogenomics/proteomics/metabolomics
• Drug discovery and development
• Establishment of a pediatric precision medicine database

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Editors

Shanghai Children's Medical Center

Beijing Children’s Hospital, Capital Medical University

Brown University

Department of Medicine, Icahn School of Medicine at Mount Sinai

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Frontiers in Pharmacology

Obstetric and Pediatric Pharmacology

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Frontiers in Pediatrics

Obstetric and Pediatric Pharmacology

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