Metabolic disorders such as diabetes have become a major health concern worldwide. With the development of modern biotechniques, emerging evidence supports the notion that protein post-translational modifications (PTMs) are playing a pivotal role in the progression and development of metabolic disorders. These protein PTMs play a critical role in cell signaling and are thus potentially involved in the initiation, development, and treatment of various metabolic disorders. Currently a variation of protein PTMs - including acetylation, phosphorylation, glycosylation, sumoylation, and ubiquitination events - have been associated with metabolic disorders and novel regulatory mechanisms are continuously suggested. Therefore, investigating the molecular mechanisms of protein PTMs in metabolic disorders is critical and necessary to understand the progression of these diseases and lead the way to more efficient therapies.
This Research Topic aims to collect cutting-edge research articles that address the important roles of protein PTMs in the development, diagnosis, prognosis, and treatment of metabolic disorders. These articles will reflect the most recent achievements in this field and shed novel insights into the mechanisms of metabolic disorders and the potential of focusing on protein PTMs for translational medicine.
Areas to be covered in this Research Topic may include, but are not limited to:
• Novel insights into the molecular mechanisms behind protein PTMs in various metabolic disorders, including - but not limited to - diabetes, obesity, metabolic liver diseases, kidney diseases etc.
• Genetic components that affect protein PTMs and intracellular functions and metabolic disorders.
• Novel genomic and proteomic analysis techniques to identify protein PTMs as novel biomarkers for metabolic disorders.
• Novel bioinformatics approaches and databases for protein PTMs analysis and prediction in relation to metabolic disorders.
Metabolic disorders such as diabetes have become a major health concern worldwide. With the development of modern biotechniques, emerging evidence supports the notion that protein post-translational modifications (PTMs) are playing a pivotal role in the progression and development of metabolic disorders. These protein PTMs play a critical role in cell signaling and are thus potentially involved in the initiation, development, and treatment of various metabolic disorders. Currently a variation of protein PTMs - including acetylation, phosphorylation, glycosylation, sumoylation, and ubiquitination events - have been associated with metabolic disorders and novel regulatory mechanisms are continuously suggested. Therefore, investigating the molecular mechanisms of protein PTMs in metabolic disorders is critical and necessary to understand the progression of these diseases and lead the way to more efficient therapies.
This Research Topic aims to collect cutting-edge research articles that address the important roles of protein PTMs in the development, diagnosis, prognosis, and treatment of metabolic disorders. These articles will reflect the most recent achievements in this field and shed novel insights into the mechanisms of metabolic disorders and the potential of focusing on protein PTMs for translational medicine.
Areas to be covered in this Research Topic may include, but are not limited to:
• Novel insights into the molecular mechanisms behind protein PTMs in various metabolic disorders, including - but not limited to - diabetes, obesity, metabolic liver diseases, kidney diseases etc.
• Genetic components that affect protein PTMs and intracellular functions and metabolic disorders.
• Novel genomic and proteomic analysis techniques to identify protein PTMs as novel biomarkers for metabolic disorders.
• Novel bioinformatics approaches and databases for protein PTMs analysis and prediction in relation to metabolic disorders.