Protecting the natural environment, while safeguarding human health has been essential for any research when it comes to identifying and regulating environmental toxic substances that reduce harmful exposures on the human body. The effect of these environmental exposures, such as toxic chemicals, air pollution, and biological agents represents a global challenge in human health and disease, such as in cancer and neurological pathologies. There is accumulating evidence leading to considerable concerns about molecular disorders developing into life threatening diseases such as cancer, and neurological pathologies. Natural bioactive compounds coming from medicinal plants possess great potential to combat the effects from toxic substances and improve the outcome and lives of people. Natural products have been commonly used in the prevention and treatment of many different human diseases given their multifaceted action, such as against cancer, anti-inflammatory diseases and neurological disorders. In this research topic we explore the potential role of extracts (complex mixtures) and pure natural product to counteract the processes of carcinogenic pollutants, including potential anticancer, anti-inflammatory and antioxidative effects , through inhibitory enzyme-based screening of natural products. We welcome researchers in Natural products, pharmacologists, biotechnologists, and other can to contribute to this research topic.
This Research Topic will showcase significant and recent contributions that integrate issues of carcinogenic pollutants, their impact on cancer and neurological pathologies, and how to investigate the therapeutic potential of natural products originating from medicinal plants as enzyme inhibitors.
Studies dealing with the nutrition, environmental chemistry, botany, toxicology of the above mentioned aspects are also welcome.
We welcome submission of Original Research and Review articles that address the following themes, including but not limited to:
• New techniques to assess potential pharmacological uses of enzyme inhibitors coming from natural resources or natural products, including molecular biology.
• Modes of action of natural plant products with an ethnopharmacology application
Important note: Authors must clearly and briefly identify what novel ethnopharmacological effect(s) or mechanism(s) are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included to provide information on NOAEL/LOAEL values. Manuscripts describing research involving the following areas will not be considered: materials/substances of only local interest materials/substances for which the chemical composition is not clearly defined only pharmacological properties, or potentially beneficial effects using in vitro or in vivo systems chemical analyses of toxins in foods without addressing the toxic, pharmacological and/or ethnopharmacological implication to humans [risk assessment should be included] unrealistic human doses, inappropriate route of exposure, or in vitro experiments that do not reflect serum levels in humans.
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All the manuscripts submitted to the collection will need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).
