Hepatocellular carcinoma (HCC) is among the most malignant tumors worldwide and the third leading cause of cancer-related mortality. The survival rate ranges from several years to a few months, in accordance mainly to the disease stage, and often remains unpredictable in the current clinical settings. Epidemiologically the spread of the metabolic associated conditions supporting non-alcoholic fatty liver disease onset worldwide, together with the alcohol abuse and the viral chronic damage, represent the main reasons concerting its onset and evolution.
HCC treatment as well is directly linked to the stage at the diagnosis and engages a series of loco-regional interventions and combined strategies involving systemic treatments and the liver transplant. Regarding chemotherapy recent discoveries shed light on new potentially useful strategies even if, globally, the response rate target seems to need some major improvements to support the burden of the disease.
For these reasons is important to identify novel biomarkers in HCC to provide the best clinical treatment and to better predict the prognosis.
With this Research Topic, we aim to collect the recent advances in the discovery of new prognostic factors for hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is among the most malignant tumors worldwide and the third leading cause of cancer-related mortality. The survival rate ranges from several years to a few months, in accordance mainly to the disease stage, and often remains unpredictable in the current clinical settings. Epidemiologically the spread of the metabolic associated conditions supporting non-alcoholic fatty liver disease onset worldwide, together with the alcohol abuse and the viral chronic damage, represent the main reasons concerting its onset and evolution.
HCC treatment as well is directly linked to the stage at the diagnosis and engages a series of loco-regional interventions and combined strategies involving systemic treatments and the liver transplant. Regarding chemotherapy recent discoveries shed light on new potentially useful strategies even if, globally, the response rate target seems to need some major improvements to support the burden of the disease.
For these reasons is important to identify novel biomarkers in HCC to provide the best clinical treatment and to better predict the prognosis.
With this Research Topic, we aim to collect the recent advances in the discovery of new prognostic factors for hepatocellular carcinoma.
