Fertility preservation is the process of saving gametes, embryos, gonadal tissues and/or gonadal cells for individuals who are at risk of infertility due to disease, medical treatments, age, genetics, or other circumstances.
Currently, oocytes, sperm, or embryos cryopreservation are established fertility preservation methods for adult patients to produce biologically related offspring with assisted reproductive technologies. These options are not available to adults who cannot delay the start of chemotherapy or to pre-pubertal patients who are not yet generating mature oocytes or sperm. Gonadal cells/tissues have been frozen for thousands of those patients worldwide with anticipation that next-generation reproductive technologies will be available in the future.
Ovarian tissue cryopreservation/transplantation, is one of these technique successfully transforming from an experimental method into clinical practice. With over 130 live births to date from its introduction to the clinic in 2004, ovarian tissue transplantation is proved to be sufficient to restore fertility and endocrine function, and is no longer labeled as “experimental”. However, there are concerns about the graft’s survival after transplantation and the potential risk of reimplantation of tumor cells. Other next-generation reproductive technologies are developing using animal models and within laboratory settings, such as in vitro maturation of immature follicles, in vitro growth of primordial follicles, artificial ovary, testicular tissue grafting, spermatogonial stem cell transplantation, in vitro gametes from pluripotent stem cells. In the future, these technologies have the potential to translated into clinical practice.
With this research topic, we would like to focus on the safety and long-term follow-up of ovarian tissue transplantation. We also review the rapid improvements in next-generation reproductive technologies for fertility preservation in both males and females.
We welcome submissions of Original Research and Review Articles focusing on the research themes including, but not limited to:
• Safety and long-term follow-up of ovarian tissue transplantation.
• In vitro growth of human/non-human primate follicles
• In vitro maturation of immature human/non-human primate follicles
• Artificial ovary implantation
• Innovations/ New techniques in fertility preservation
• In vitro gametes from pluripotent stem cells and their application in fertility preservation
• Spermatogonial stem cell transplantation and testicular tissue grafting in human/non-human primate and its safety control
Fertility preservation is the process of saving gametes, embryos, gonadal tissues and/or gonadal cells for individuals who are at risk of infertility due to disease, medical treatments, age, genetics, or other circumstances.
Currently, oocytes, sperm, or embryos cryopreservation are established fertility preservation methods for adult patients to produce biologically related offspring with assisted reproductive technologies. These options are not available to adults who cannot delay the start of chemotherapy or to pre-pubertal patients who are not yet generating mature oocytes or sperm. Gonadal cells/tissues have been frozen for thousands of those patients worldwide with anticipation that next-generation reproductive technologies will be available in the future.
Ovarian tissue cryopreservation/transplantation, is one of these technique successfully transforming from an experimental method into clinical practice. With over 130 live births to date from its introduction to the clinic in 2004, ovarian tissue transplantation is proved to be sufficient to restore fertility and endocrine function, and is no longer labeled as “experimental”. However, there are concerns about the graft’s survival after transplantation and the potential risk of reimplantation of tumor cells. Other next-generation reproductive technologies are developing using animal models and within laboratory settings, such as in vitro maturation of immature follicles, in vitro growth of primordial follicles, artificial ovary, testicular tissue grafting, spermatogonial stem cell transplantation, in vitro gametes from pluripotent stem cells. In the future, these technologies have the potential to translated into clinical practice.
With this research topic, we would like to focus on the safety and long-term follow-up of ovarian tissue transplantation. We also review the rapid improvements in next-generation reproductive technologies for fertility preservation in both males and females.
We welcome submissions of Original Research and Review Articles focusing on the research themes including, but not limited to:
• Safety and long-term follow-up of ovarian tissue transplantation.
• In vitro growth of human/non-human primate follicles
• In vitro maturation of immature human/non-human primate follicles
• Artificial ovary implantation
• Innovations/ New techniques in fertility preservation
• In vitro gametes from pluripotent stem cells and their application in fertility preservation
• Spermatogonial stem cell transplantation and testicular tissue grafting in human/non-human primate and its safety control