The tumor microenvironment is a complex ecology that evolves with cancer cells and provides support during malignant transformation. The TME comprises various cell types (endothelial cells, fibroblasts, immune cells, etc.) and extracellular components (cytokines, growth factors, hormones, extracellular matrix, etc.) that are surrounding tumor cells and nourished by a vascular network.
The TME not only plays a pivotal role during tumor initiation, progression, and metastasis but also has profound effects on therapeutic efficacy. Therefore, understanding the interaction and signaling that occur in the TME is critical for the management of cancer.
Outside-in and inside-out signaling represents the network of cell communications. The signals exchanged by cells in the tumor microenvironment may concern proliferation and differentiation, adhesion and motility, survival and death.
The aim of this Research Topic is to collate original research and review articles that will aid in uncovering the complex events in tumor microenvironment and cell signaling.
Potential topics include but are not limited to the following:
- The spatial and temporal distribution of TME cells
- Crosstalk between the nervous system and TME
- Cancer cell-immune cell interaction in TME
- The endocrine system and cell signaling
- Clinical perspectives of TME and cell signaling
- Metabolism reprogramming in cancer cells and TME cells
The tumor microenvironment is a complex ecology that evolves with cancer cells and provides support during malignant transformation. The TME comprises various cell types (endothelial cells, fibroblasts, immune cells, etc.) and extracellular components (cytokines, growth factors, hormones, extracellular matrix, etc.) that are surrounding tumor cells and nourished by a vascular network.
The TME not only plays a pivotal role during tumor initiation, progression, and metastasis but also has profound effects on therapeutic efficacy. Therefore, understanding the interaction and signaling that occur in the TME is critical for the management of cancer.
Outside-in and inside-out signaling represents the network of cell communications. The signals exchanged by cells in the tumor microenvironment may concern proliferation and differentiation, adhesion and motility, survival and death.
The aim of this Research Topic is to collate original research and review articles that will aid in uncovering the complex events in tumor microenvironment and cell signaling.
Potential topics include but are not limited to the following:
- The spatial and temporal distribution of TME cells
- Crosstalk between the nervous system and TME
- Cancer cell-immune cell interaction in TME
- The endocrine system and cell signaling
- Clinical perspectives of TME and cell signaling
- Metabolism reprogramming in cancer cells and TME cells