Spontaneous Preterm Birth (PTB) is a deleterious consequence of sustained Preterm Labor (PTL) and/or Preterm Premature Rupture of Membranes (PPROM) and is associated with neonatal morbidities such as higher susceptibility to infections, pulmonary dysplasia, necrotizing enterocolitis, and mortality, being the cause of 28% of early neonatal deaths (excluding malformations). Several risk factors, such as bacterial vaginosis, intrauterine infections, genetic predisposition, socioeconomic factors, and behavioral habits have already been associated with PTL and PPROM. Unfortunately, and despite extensive research, rates of prematurity in most countries have not decreased significantly over the last years. The literature points out several dysregulated molecular mechanisms that culminate in PTB such as apoptotic, senescence-related, and especially, inflammatory pathways. In this context, a deeper knowledge of the immunopathogenesis of spontaneous preterm birth is key to the development of new strategies for prematurity prediction and prevention.
Preterm birth has achieved stable rates over the last decades and across different nations. To decrease prematurity rates a clear understanding of the mechanisms underlying this condition is required, along with the adequate identification of high-risk pregnancies and their proper management. The purpose of this article collection is to reunite recent advances regarding the immunopathologic aspects underlying preterm birth pathways and updated methodologies for PTB and PPROM prediction. The goal of this collection is to provide the readers with a compilation of quality, updated, and reliable information that will allow them to draw a mental map of routes leading to preterm birth as well as new strategies to tackle the subject.
The scope for this Research Topic will be the immunopathologic mechanisms underlying spontaneous preterm birth pathways and biomarkers for prematurity prediction. Thus, we welcome authors to submit Original Research, Review, and Mini Reviews on the following topics:
? Immunopathogenesis of preterm birth
? Molecular pathogenesis of prematurity
? Inflammatory and immunological biomarkers studies on adverse pregnancies
? Immune response to local pathogens and impact on birth pathways
? Role of extracellular vesicles in preterm pregnancy
? Maternal-fetal communication triggering preterm birth
? Immune disorders and related preterm pregnancy effects
Spontaneous Preterm Birth (PTB) is a deleterious consequence of sustained Preterm Labor (PTL) and/or Preterm Premature Rupture of Membranes (PPROM) and is associated with neonatal morbidities such as higher susceptibility to infections, pulmonary dysplasia, necrotizing enterocolitis, and mortality, being the cause of 28% of early neonatal deaths (excluding malformations). Several risk factors, such as bacterial vaginosis, intrauterine infections, genetic predisposition, socioeconomic factors, and behavioral habits have already been associated with PTL and PPROM. Unfortunately, and despite extensive research, rates of prematurity in most countries have not decreased significantly over the last years. The literature points out several dysregulated molecular mechanisms that culminate in PTB such as apoptotic, senescence-related, and especially, inflammatory pathways. In this context, a deeper knowledge of the immunopathogenesis of spontaneous preterm birth is key to the development of new strategies for prematurity prediction and prevention.
Preterm birth has achieved stable rates over the last decades and across different nations. To decrease prematurity rates a clear understanding of the mechanisms underlying this condition is required, along with the adequate identification of high-risk pregnancies and their proper management. The purpose of this article collection is to reunite recent advances regarding the immunopathologic aspects underlying preterm birth pathways and updated methodologies for PTB and PPROM prediction. The goal of this collection is to provide the readers with a compilation of quality, updated, and reliable information that will allow them to draw a mental map of routes leading to preterm birth as well as new strategies to tackle the subject.
The scope for this Research Topic will be the immunopathologic mechanisms underlying spontaneous preterm birth pathways and biomarkers for prematurity prediction. Thus, we welcome authors to submit Original Research, Review, and Mini Reviews on the following topics:
? Immunopathogenesis of preterm birth
? Molecular pathogenesis of prematurity
? Inflammatory and immunological biomarkers studies on adverse pregnancies
? Immune response to local pathogens and impact on birth pathways
? Role of extracellular vesicles in preterm pregnancy
? Maternal-fetal communication triggering preterm birth
? Immune disorders and related preterm pregnancy effects
