Renal cell carcinoma (RCC) is one of the most common cancers of the urinary system with a low survival rate and poor prognosis. As RCC has been found to be highly resistant to chemotherapy and radiotherapy, surgical treatment involving the removal of the primary kidney tumor by nephrectomy in localized RCC (loRCC) is the standard treatment used for RCC patients. However, once the RCC advances in stages or becomes metastatic, the 5-year overall survival rate decreases from approximately 90% to less than 30% for localized RCC. Furthermore, approximately 30-50% of patients who are treated with surgical treatment for loRCC have experienced disease recurrence within two years, significantly reducing the survival rate less than 30%. Therefore, further studies are required to identify and explore how disease recurrence occurs and potential diagnostic methods after nephrectomy to detect them as early possible to provide therapeutic strategies and improve the survival rate and prognosis of loRCC patients.
There are currently two forms of nephrectomy, radical nephrectomy (RN) which is found to be used for renal tumors of clinical T staging T2 or in patients with loRCC who are not able to be treated with nephron preservation. However, studies have demonstrated patients with localized T1a-b renal tumors, PN and RN have similar impact and effect. However, further studies have highlighted that PN has a greater survival rate for loRCC patients with T1 stage renal tumors as they have less post-operative renal function decline compared to patients treated with RN. However, there are various factors which influence the 10-year overall survival rate of patients with T1 stage renal tumors including the patient's age, lifestyle and other factors but the surgical method is dependent primarily on the surgeon's preference and experience. RN has been most preferable for treating T2 stage and larger renal tumors. However, significant challenges with this surgical method involve higher higher risk of post-operative renal insufficiency and post-operative bleeding. The choice of surgical method remains controversial and further studies are required to identify how it impacts loRCC patients.
The goal of this Research Topic is to explore how nephrectomy impacts localized renal cell carcinoma and how to identify potential early detection and diagnostic tools to improve the survival rate and prognosis. This topic also aims to explore the impact and challenges of radical nephrectomy and partial nephrectomy on localized renal cell carcinoma. We welcome Original Research Articles, Review Articles and Systematic Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Renal cell carcinoma (RCC) is one of the most common cancers of the urinary system with a low survival rate and poor prognosis. As RCC has been found to be highly resistant to chemotherapy and radiotherapy, surgical treatment involving the removal of the primary kidney tumor by nephrectomy in localized RCC (loRCC) is the standard treatment used for RCC patients. However, once the RCC advances in stages or becomes metastatic, the 5-year overall survival rate decreases from approximately 90% to less than 30% for localized RCC. Furthermore, approximately 30-50% of patients who are treated with surgical treatment for loRCC have experienced disease recurrence within two years, significantly reducing the survival rate less than 30%. Therefore, further studies are required to identify and explore how disease recurrence occurs and potential diagnostic methods after nephrectomy to detect them as early possible to provide therapeutic strategies and improve the survival rate and prognosis of loRCC patients.
There are currently two forms of nephrectomy, radical nephrectomy (RN) which is found to be used for renal tumors of clinical T staging T2 or in patients with loRCC who are not able to be treated with nephron preservation. However, studies have demonstrated patients with localized T1a-b renal tumors, PN and RN have similar impact and effect. However, further studies have highlighted that PN has a greater survival rate for loRCC patients with T1 stage renal tumors as they have less post-operative renal function decline compared to patients treated with RN. However, there are various factors which influence the 10-year overall survival rate of patients with T1 stage renal tumors including the patient's age, lifestyle and other factors but the surgical method is dependent primarily on the surgeon's preference and experience. RN has been most preferable for treating T2 stage and larger renal tumors. However, significant challenges with this surgical method involve higher higher risk of post-operative renal insufficiency and post-operative bleeding. The choice of surgical method remains controversial and further studies are required to identify how it impacts loRCC patients.
The goal of this Research Topic is to explore how nephrectomy impacts localized renal cell carcinoma and how to identify potential early detection and diagnostic tools to improve the survival rate and prognosis. This topic also aims to explore the impact and challenges of radical nephrectomy and partial nephrectomy on localized renal cell carcinoma. We welcome Original Research Articles, Review Articles and Systematic Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
