The aging process affects each individual that celebrated their midlife birthday. In addition to being a major risk factor for majority of chronic diseases, aging increases frailty and decreases quality of life. Despite huge body of research on various hallmarks of aging the field is still struggling to bring a longevity intervention to the market. Many studies focus on one aspect of the senescence or age-related changes rather than considering a bigger picture. Aging and age-related diseases are multi-layer dysfunctions that involve every aspect of cellular life (from genetics to epigenetics, from nucleus to cellular membrane), extracellular matrix, and higher-order interactions like cell-to-cell and between-organ communications. The discovery of successful interventions against aging and age-related diseases require systemic approaches that capture its complexity. This is true for any organ system, however, nervous system possess another level of complexity:
1) it is not accessible to most of the drugs, 2) different tissues and parts of the tissues age at different rates, 3) it has high variability of cell types and functions, and thus systemic approach has the greatest potential to reveal interventions against aging and age-related diseases of nervous system.
To tackle these problems we suggest the Research Topic titled “System approaches for discovery of interventions against aging and age-related diseases”. We welcome original research articles and reviews that cover areas including but not limited to:
1) Prediction of new interventions (genetic, pharmacological or lifestyle) that target aging or age-related diseases of nervous system using omics data
2) Prediction of new therapeutic targets for aging or age-related diseases of nervous system using omics data
3) Multi-omics studies of aging and age-related diseases of nervous system
4) Biomarkers of aging and age-related diseases of nervous system
5) Delivery of interventions to central nervous system
The aging process affects each individual that celebrated their midlife birthday. In addition to being a major risk factor for majority of chronic diseases, aging increases frailty and decreases quality of life. Despite huge body of research on various hallmarks of aging the field is still struggling to bring a longevity intervention to the market. Many studies focus on one aspect of the senescence or age-related changes rather than considering a bigger picture. Aging and age-related diseases are multi-layer dysfunctions that involve every aspect of cellular life (from genetics to epigenetics, from nucleus to cellular membrane), extracellular matrix, and higher-order interactions like cell-to-cell and between-organ communications. The discovery of successful interventions against aging and age-related diseases require systemic approaches that capture its complexity. This is true for any organ system, however, nervous system possess another level of complexity:
1) it is not accessible to most of the drugs, 2) different tissues and parts of the tissues age at different rates, 3) it has high variability of cell types and functions, and thus systemic approach has the greatest potential to reveal interventions against aging and age-related diseases of nervous system.
To tackle these problems we suggest the Research Topic titled “System approaches for discovery of interventions against aging and age-related diseases”. We welcome original research articles and reviews that cover areas including but not limited to:
1) Prediction of new interventions (genetic, pharmacological or lifestyle) that target aging or age-related diseases of nervous system using omics data
2) Prediction of new therapeutic targets for aging or age-related diseases of nervous system using omics data
3) Multi-omics studies of aging and age-related diseases of nervous system
4) Biomarkers of aging and age-related diseases of nervous system
5) Delivery of interventions to central nervous system
