From Joseph John Thomson to John Bennet Fenn, from Peter Roepstorff to John Yates III, the mass spectrometry field has evolved as a science, as well as a cutting-edge tool to modern scientists and clinicians. From innovative techniques in Physics and Chemistry Nobel prizes, it has become the most widespread and versatile tool in large scale Metabolomics and Proteomics, with scientific capabilities ranging from Forensic Imaging to Single Cell analysis. Since the enlightened vision of Thomson’s application in Chemistry, mass spectrometry has inspired new and novel applications in a variety of applied scientific fields.
In Pharmaceutical Science, as a natural compounds prospection tool in cancer research, mass spectrometry has undergone numerous developments and evolutions, from high throughput screening for antitumoral active products to validation of therapeutic targets, being widely used in de novo drug research and in vaccine production, to enabling and leveraging the possibilities of tailor-made, patient specific medicines. In Translational Medicine, mass spectrometry is being used as a complementary tool to evaluate conditions at patients’ risk stratification, predictive evaluation within orthotopic transplants and the recent approach to predictive detection and early metabolic imbalance in SARS-CoV2.
In Oncology, mass spectrometry has proved invaluable in potential biomarker screening, as well as immunotherapy monitoring and tissue characterization through imaging; although its most important application is represented by ‘MassSpec Pen’ and ‘iKnife’ tools in surgery rooms. Moreover, an even brighter future for MS is expected using data integration analysis powered by Artificial Intelligence strategies, aiming for its most comprehensive application, highlighted in Translational Medicine and Health Science areas. With high sensitivity and specificity, alongside its capability to provide faster results and rapid clinical feedback, mass spectrometry is undoubtedly one the most powerful tools in the field of oncology. Its relevance in life research analysis as a valuable potential tool to guide immediate medical decisions is presented in this series of original articles, opinions and reviews, collected together within this Research Topic.
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
From Joseph John Thomson to John Bennet Fenn, from Peter Roepstorff to John Yates III, the mass spectrometry field has evolved as a science, as well as a cutting-edge tool to modern scientists and clinicians. From innovative techniques in Physics and Chemistry Nobel prizes, it has become the most widespread and versatile tool in large scale Metabolomics and Proteomics, with scientific capabilities ranging from Forensic Imaging to Single Cell analysis. Since the enlightened vision of Thomson’s application in Chemistry, mass spectrometry has inspired new and novel applications in a variety of applied scientific fields.
In Pharmaceutical Science, as a natural compounds prospection tool in cancer research, mass spectrometry has undergone numerous developments and evolutions, from high throughput screening for antitumoral active products to validation of therapeutic targets, being widely used in de novo drug research and in vaccine production, to enabling and leveraging the possibilities of tailor-made, patient specific medicines. In Translational Medicine, mass spectrometry is being used as a complementary tool to evaluate conditions at patients’ risk stratification, predictive evaluation within orthotopic transplants and the recent approach to predictive detection and early metabolic imbalance in SARS-CoV2.
In Oncology, mass spectrometry has proved invaluable in potential biomarker screening, as well as immunotherapy monitoring and tissue characterization through imaging; although its most important application is represented by ‘MassSpec Pen’ and ‘iKnife’ tools in surgery rooms. Moreover, an even brighter future for MS is expected using data integration analysis powered by Artificial Intelligence strategies, aiming for its most comprehensive application, highlighted in Translational Medicine and Health Science areas. With high sensitivity and specificity, alongside its capability to provide faster results and rapid clinical feedback, mass spectrometry is undoubtedly one the most powerful tools in the field of oncology. Its relevance in life research analysis as a valuable potential tool to guide immediate medical decisions is presented in this series of original articles, opinions and reviews, collected together within this Research Topic.
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
