Cell division controls the proper segregation of genomic and cytoplasmic material between the two daughter cells, which is crucial for establishing cell identity and fate, and for correct tissue and organ formation. Precise regulatory mechanisms control the accuracy, progression and fidelity of the mitotic processes, from the assembly of the mitotic spindle and chromosome alignment in prometaphase and metaphase, to chromosome segregation, nuclear reformation and daughter cell separation during mitotic exit and cytokinesis.
Mitotic exit and cytokinesis involve a remarkable re-organization of the cytoskeleton and chromatin, including the formation and contraction of the actomyosin ring and the assembly of the central spindle, an array of antiparallel and interdigitating microtubules that forms between the segregating chromosomes. It also requires the addition of new membrane at the cleavage site, the reformation of the nuclear envelope around the segregated chromatin, and the physical separation, i.e., abscission, of the two daughter cells. All these events are regulated by highly coordinated and finely tuned signaling and protein-protein interaction networks.
The aim of this Research Topic is to describe recent advances in our understanding of the mechanisms that regulate mitotic exit and cytokinesis.
Areas to be covered in this Research Topic may include, but are not limited to:
• Regulation of the assembly and dynamics of microtubules and actomyosin filaments after anaphase onset.
• Intrinsic and extrinsic signaling pathways controlling exit from mitosis and cytokinesis.
• Post-translational modifications (PTMs) and their cross-talks.
• Membrane trafficking during mitotic exit and cytokinesis.
• Mechanics and regulation of abscission.
• Chromatin remodeling.
• Get set- Ready – Go for the next cell cycle.
Cell division controls the proper segregation of genomic and cytoplasmic material between the two daughter cells, which is crucial for establishing cell identity and fate, and for correct tissue and organ formation. Precise regulatory mechanisms control the accuracy, progression and fidelity of the mitotic processes, from the assembly of the mitotic spindle and chromosome alignment in prometaphase and metaphase, to chromosome segregation, nuclear reformation and daughter cell separation during mitotic exit and cytokinesis.
Mitotic exit and cytokinesis involve a remarkable re-organization of the cytoskeleton and chromatin, including the formation and contraction of the actomyosin ring and the assembly of the central spindle, an array of antiparallel and interdigitating microtubules that forms between the segregating chromosomes. It also requires the addition of new membrane at the cleavage site, the reformation of the nuclear envelope around the segregated chromatin, and the physical separation, i.e., abscission, of the two daughter cells. All these events are regulated by highly coordinated and finely tuned signaling and protein-protein interaction networks.
The aim of this Research Topic is to describe recent advances in our understanding of the mechanisms that regulate mitotic exit and cytokinesis.
Areas to be covered in this Research Topic may include, but are not limited to:
• Regulation of the assembly and dynamics of microtubules and actomyosin filaments after anaphase onset.
• Intrinsic and extrinsic signaling pathways controlling exit from mitosis and cytokinesis.
• Post-translational modifications (PTMs) and their cross-talks.
• Membrane trafficking during mitotic exit and cytokinesis.
• Mechanics and regulation of abscission.
• Chromatin remodeling.
• Get set- Ready – Go for the next cell cycle.