Poultry eggs and meat are the universally accepted source of food protein and are crucial for global food security. Effective control of infectious diseases in poultry by immunization with vaccines is a prerequisite to the advance in the poultry industry. Quality vaccines with optimal protection are always highly expected and in great demand in practice. However, when chickens were afflicted with immunosuppressive diseases after infection with immunosuppressive viruses such as infectious bursal disease virus (IBDV), Marek’s disease virus (MDV), Avian leucosis virus (ALV), chicken infectious anemia virus (CIAV), or others, the survival or recovered chickens display compromised immune response and increased susceptibility to secondary infections, causing severe economic losses to stakeholders. Furthermore, the immunosuppressive virus, once circulating in flocks without apparent clinical signs, may also remarkably affect the efficacy of vaccines and even result in vaccination failure in control of other diseases such as Avian Influenza (AI) and/or New Castle Disease (ND). Thus, timely and effective control of immunosuppressive disease is vital to the success in control of other diseases in poultry Recently most of the studies were focused on understanding the interaction of host and immunosuppressive virus, publishing a number of important findings and significantly furthering our knowledge of avian immunosuppressive disease.
The goal of this Research Topic is to collect contributions on progress made in understanding the immunosuppressive disease in poultry, especially the mechanism of virus-mediated immunosuppression, persistent infection, pathogen-host interactions, innate immune response, signal transduction, cytokine expressions, and roles of microRNAs in host antidefense response. We also aim to collect contributions on progress made in understanding avian immune system the roles of natural killer cells, heterophils, macrophages, and dendritic cells in host response to pathogenic infection. Special interest may also be contributions that characterized new subsets of immune cells (if any), which are corresponding counterparts to mammalian NKT, gamma-delta T cells and innate lymphoid cells (ILCs), and those that highlight the novel vaccine development, diagnosis, and control of avian immunosuppressive diseases.
We welcome the submission of Review, Mini Review, and Original Research articles that address the following sub-topics:
• Mechanism of persistent infection of immunosuppressive pathogens
• Interaction of pathogens (virus, bacterium, parasite) with host
• Avian immune response to pathogenic infections
• Roles of microRNAs in the host response
• Roles of anti-microbial peptides in host response and the mechanisms
• Pathogenesis of immunosuppressive virus infection
• Pattern recognition receptors and downstream signaling pathways
• Innate immune cells /regulation of immune response
• Novel vaccine development /diagnostic methods for poultry disease
Poultry eggs and meat are the universally accepted source of food protein and are crucial for global food security. Effective control of infectious diseases in poultry by immunization with vaccines is a prerequisite to the advance in the poultry industry. Quality vaccines with optimal protection are always highly expected and in great demand in practice. However, when chickens were afflicted with immunosuppressive diseases after infection with immunosuppressive viruses such as infectious bursal disease virus (IBDV), Marek’s disease virus (MDV), Avian leucosis virus (ALV), chicken infectious anemia virus (CIAV), or others, the survival or recovered chickens display compromised immune response and increased susceptibility to secondary infections, causing severe economic losses to stakeholders. Furthermore, the immunosuppressive virus, once circulating in flocks without apparent clinical signs, may also remarkably affect the efficacy of vaccines and even result in vaccination failure in control of other diseases such as Avian Influenza (AI) and/or New Castle Disease (ND). Thus, timely and effective control of immunosuppressive disease is vital to the success in control of other diseases in poultry Recently most of the studies were focused on understanding the interaction of host and immunosuppressive virus, publishing a number of important findings and significantly furthering our knowledge of avian immunosuppressive disease.
The goal of this Research Topic is to collect contributions on progress made in understanding the immunosuppressive disease in poultry, especially the mechanism of virus-mediated immunosuppression, persistent infection, pathogen-host interactions, innate immune response, signal transduction, cytokine expressions, and roles of microRNAs in host antidefense response. We also aim to collect contributions on progress made in understanding avian immune system the roles of natural killer cells, heterophils, macrophages, and dendritic cells in host response to pathogenic infection. Special interest may also be contributions that characterized new subsets of immune cells (if any), which are corresponding counterparts to mammalian NKT, gamma-delta T cells and innate lymphoid cells (ILCs), and those that highlight the novel vaccine development, diagnosis, and control of avian immunosuppressive diseases.
We welcome the submission of Review, Mini Review, and Original Research articles that address the following sub-topics:
• Mechanism of persistent infection of immunosuppressive pathogens
• Interaction of pathogens (virus, bacterium, parasite) with host
• Avian immune response to pathogenic infections
• Roles of microRNAs in the host response
• Roles of anti-microbial peptides in host response and the mechanisms
• Pathogenesis of immunosuppressive virus infection
• Pattern recognition receptors and downstream signaling pathways
• Innate immune cells /regulation of immune response
• Novel vaccine development /diagnostic methods for poultry disease