Tumor microenvironment is an ecosystem that supports tumor growth and metastasis, modulates the immune response, and resists therapeutics. Detailed understanding of this ecosystem can help elucidating disease mechanisms and develop therapeutic strategies, but it is considerably challenging. To date, there remains much unknown about how this ecosystem adapts to changing conditions or how the dynamic interactions between tumor and the immune system evolve upon disease progression. In addition, studies of tumor microenvironment is further confounded by the significant intra- and inter-tumoral heterogeneity, which calls for single-cell analytical approaches such as single-cell sequencing, spatial transcriptomics and proteomics, and novel imaging approaches. On the other hand, cancer immunotherapies, including adoptive T cell transfer, immune checkpoint blockade, and neoantigen-based cancer vaccines, have provided paradigm shifts in treating cancer patients by modulating the immune response. However, the low percentage of responders, acquired therapy resistance, hyperprogression, and severe side effects remain unsolved. These knowledge gaps necessitate more studies to enrich the fundamental understanding of the dynamic tumor-immune interplay. This Research Topic calls for new technologies, biological findings, and therapies targeting the tumor microenvironment and the tumor-immune interplay.
This Research Topic aims at making use of single-cell sequencing technologies, spatial transcriptomics and proteomics, as well as novel imaging approaches to resolve molecular landscape of tumor microenvironment and its dynamic evolution and complex tumor-immune interplay at the single-cell level for a fundamental understanding of cancer biology, improving immune therapy and development of new microenvironment-targeted therapy.
We welcome Original Research, Review and Clinical Trials covering, but not limited, to the following subtopics:
• New technologies for resolving tumor microenvironment and tumor-immune interplay
• Profiling intra- and intertumoral heterogeneity pertinent to the local microenvironment
• Elucidating how cellular heterogeneity shapes the tumor microenvironment
• Identification and validation of critical soluble factors in the tumor microenvironment
• High-dimensional single-cell characterization of dynamic immune response
Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Tumor microenvironment is an ecosystem that supports tumor growth and metastasis, modulates the immune response, and resists therapeutics. Detailed understanding of this ecosystem can help elucidating disease mechanisms and develop therapeutic strategies, but it is considerably challenging. To date, there remains much unknown about how this ecosystem adapts to changing conditions or how the dynamic interactions between tumor and the immune system evolve upon disease progression. In addition, studies of tumor microenvironment is further confounded by the significant intra- and inter-tumoral heterogeneity, which calls for single-cell analytical approaches such as single-cell sequencing, spatial transcriptomics and proteomics, and novel imaging approaches. On the other hand, cancer immunotherapies, including adoptive T cell transfer, immune checkpoint blockade, and neoantigen-based cancer vaccines, have provided paradigm shifts in treating cancer patients by modulating the immune response. However, the low percentage of responders, acquired therapy resistance, hyperprogression, and severe side effects remain unsolved. These knowledge gaps necessitate more studies to enrich the fundamental understanding of the dynamic tumor-immune interplay. This Research Topic calls for new technologies, biological findings, and therapies targeting the tumor microenvironment and the tumor-immune interplay.
This Research Topic aims at making use of single-cell sequencing technologies, spatial transcriptomics and proteomics, as well as novel imaging approaches to resolve molecular landscape of tumor microenvironment and its dynamic evolution and complex tumor-immune interplay at the single-cell level for a fundamental understanding of cancer biology, improving immune therapy and development of new microenvironment-targeted therapy.
We welcome Original Research, Review and Clinical Trials covering, but not limited, to the following subtopics:
• New technologies for resolving tumor microenvironment and tumor-immune interplay
• Profiling intra- and intertumoral heterogeneity pertinent to the local microenvironment
• Elucidating how cellular heterogeneity shapes the tumor microenvironment
• Identification and validation of critical soluble factors in the tumor microenvironment
• High-dimensional single-cell characterization of dynamic immune response
Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.