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Oxidative stress in microglia. Microglia can produce reactive oxygen species (ROS) through NOX2, mitochondrial oxidative phosphorylation, and the Fenton reaction with iron. ROS act as signaling molecules to mediate pathways pivotal in microglial functions.
4,914 views
16 citations
ISL reduced the cisplatin-induced apoptosis in HK2 cells. HK2 cells were pretreated with 125 μM ISL for 6–8 h and then incubated with 10 μg/mL cisplatin for 24 h. (A) The expression of Bcl-2 was detected by western blotting. β-actin was used as an internal reference. (B) Densitometry analysis of the western blots of Bcl-2 (n = 3 per group). (C) The expression of cleaved caspase-3 and caspase-3 was detected by western blotting. β-actin was used as an internal reference. (D) Densitometry analysis of cleaved caspase-3/caspase-3 (n = 3 per group). The quantitative results are expressed as the mean ± SD of each group. **p < 0.01, ***p < 0.001 (ANOVA with multiple comparison).
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13 citations