Inflammatory skin disorders, such as Hidradenitis Suppurativa, Psoriasis, Atopic Dermatitis, and Behçet disease, are multifactorial traits being triggered by a wide range of conditions such as genetic predisposition, allergic reactions, or exposure to environmental stimuli. Various molecular/cellular/immune mechanisms are involved in the pathogenesis of these diseases thus including the main components of the innate immune system (i.e. immune cells and structural tissue cells). The innate immune response comprises anatomical barriers as well as effector cells (such as phagocytic cells or cells that release cytokines and inflammatory mediators), antimicrobial peptides and soluble mediators.
Innate immunity could play a crucial role in the development of the chronic inflammatory phenotypes in these diseases. Despite the interest in this topic having grown considerably, the exact role of innate immunity in the pathogenesis of skin inflammatory diseases is not yet well-known, with both an innate immunodeficiency and immune hyperactivity being reported. Controversial findings have been reported so far, with conflicting data regarding the involvement of cutaneous or systemic innate immunity.
This Research Topic specifically aims at unraveling the role played by innate immunity in the pathogenesis of inflammatory skin diseases. Increased knowledge about the functions of innate immunity in the skin may provide new evidence towards our understanding of the crosstalk between Notch signaling, inflammation, and skin barrier.
Notch signaling is involved in the strict regulation of keratinocyte proliferation, differentiation, migration, and apoptosis. Both hyper- and hypo-activation of Notch signaling have been shown to contribute to the onset of various skin diseases via increased keratinocyte maturation, proliferation, and innate immune activation through the maturation of macrophages, dendritic cells, and T cells. However, more research is required to understand the contradictory relationship between Notch activity, keratinocyte proliferation and maturation, and IFN-? levels in inflammatory skin diseases.
Recently, OMICs data, in particular, RNAseq and single-cell transcriptomics technologies, are offering a great opportunity to extensively and functionally study the pathogenesis of these skin diseases. Further understanding of the role played by innate immunity may also be useful for the identification of new biomarkers as well as novel molecules playing a relevant role in inflammatory pathways.
We welcome and encourage the authors to present Original Research, Review, Mini Review, Case Report and Perspective articles that may cover any of the following aspects:
• Disorders of innate immunity and skin barrier in skin inflammatory diseases;
• Dysregulation in the expression of antimicrobial peptides and others inflammatory soluble mediators in skin inflammatory diseases;
• Innate immunity and epithelial cell differentiation;
• Correlation of Notch signalling and innate system in inflammatory skin diseases;
• Inflammatory pathways in skin diseases;
• Identification of inflammatory biomarkers to be used as a therapeutic target
Inflammatory skin disorders, such as Hidradenitis Suppurativa, Psoriasis, Atopic Dermatitis, and Behçet disease, are multifactorial traits being triggered by a wide range of conditions such as genetic predisposition, allergic reactions, or exposure to environmental stimuli. Various molecular/cellular/immune mechanisms are involved in the pathogenesis of these diseases thus including the main components of the innate immune system (i.e. immune cells and structural tissue cells). The innate immune response comprises anatomical barriers as well as effector cells (such as phagocytic cells or cells that release cytokines and inflammatory mediators), antimicrobial peptides and soluble mediators.
Innate immunity could play a crucial role in the development of the chronic inflammatory phenotypes in these diseases. Despite the interest in this topic having grown considerably, the exact role of innate immunity in the pathogenesis of skin inflammatory diseases is not yet well-known, with both an innate immunodeficiency and immune hyperactivity being reported. Controversial findings have been reported so far, with conflicting data regarding the involvement of cutaneous or systemic innate immunity.
This Research Topic specifically aims at unraveling the role played by innate immunity in the pathogenesis of inflammatory skin diseases. Increased knowledge about the functions of innate immunity in the skin may provide new evidence towards our understanding of the crosstalk between Notch signaling, inflammation, and skin barrier.
Notch signaling is involved in the strict regulation of keratinocyte proliferation, differentiation, migration, and apoptosis. Both hyper- and hypo-activation of Notch signaling have been shown to contribute to the onset of various skin diseases via increased keratinocyte maturation, proliferation, and innate immune activation through the maturation of macrophages, dendritic cells, and T cells. However, more research is required to understand the contradictory relationship between Notch activity, keratinocyte proliferation and maturation, and IFN-? levels in inflammatory skin diseases.
Recently, OMICs data, in particular, RNAseq and single-cell transcriptomics technologies, are offering a great opportunity to extensively and functionally study the pathogenesis of these skin diseases. Further understanding of the role played by innate immunity may also be useful for the identification of new biomarkers as well as novel molecules playing a relevant role in inflammatory pathways.
We welcome and encourage the authors to present Original Research, Review, Mini Review, Case Report and Perspective articles that may cover any of the following aspects:
• Disorders of innate immunity and skin barrier in skin inflammatory diseases;
• Dysregulation in the expression of antimicrobial peptides and others inflammatory soluble mediators in skin inflammatory diseases;
• Innate immunity and epithelial cell differentiation;
• Correlation of Notch signalling and innate system in inflammatory skin diseases;
• Inflammatory pathways in skin diseases;
• Identification of inflammatory biomarkers to be used as a therapeutic target
