In Celebration of Women in Science: Lipids, Membranes, and Membranous Organelles

41.1K

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53

authors

11

articles

In Celebration of Women in Science: Lipids, Membranes, and Membranous Organelles

41.1K

views

53

authors

11

articles

Editorial

13 April 2023

Editorial: In celebration of women in science: Lipids, membranes, and membranous organelles

Isabel M. López-Lara

and

Elena G. Govorunova

935 views

0 citations

Editors

2

Elena G Govorunova

University of Texas Health Science Center at Houston

Isabel María López-Lara

UNAM Campus Morelos, National Autonomous University of Mexico

Impact

Proposed mechanisms of action of daptomycin. After insertion into the cell membrane, the Ca2+-daptomycin complex oligomerize in the outer leaflet of the cell membrane. Ca2+-daptomycin oligomers are translocated to the inner leaflet of the cell membrane which result in lipid shedding, tripartite formation with phosphatidylglycerol and lipid II/UDP precursors, or membrane protein functional disruption. See text for details. ROS—reactive oxygen species, UDP—undecaprenyl. Figure produced with BioRender.

Mini Review

14 November 2022

Bacterial cell membranes and their role in daptomycin resistance: A review

April H. Nguyen

, 3 more and

Truc T. Tran

4,098 views

23 citations

Knockdown and overexpression constructs for Cr-FAX1 and Cr-FAX5 genes. (A) Schematic drawing of artificial microRNA (amiRNA) constructs for knockdown of Cr-FAX1 and Cr-FAX5. The amiRNAs directed against Chlamydomonas Cr-FAX1 (left) and Cr-FAX5 genes (right) are SpeI-subcloned into the pMS539 plasmid vector (top), which harbors the inducible NIT1 (nitrate reductase 1) promoter (for details see Schmollinger et al., 2010). The amiRNA generated by pMS539 targets regions in the second exons of Cr-FAX1 (left) and Cr-FAX5 (right), coding for amino acids 20–26 of mature Cr-FAX1 and 77–83 of Cr-FAX5, respectively. Base-pairing nucleotides of the amiRNA and Cr-FAX1, Cr-FAX5 mRNAs are shaded in turquoise. (B) Schematic drawing of level 1 constructs according to the MoClo syntax (Patron et al., 2015; Crozet et al., 2018) for overexpression of Cr-FAX1 and Cr-FAX5 genes. The following level 0 modules were assembled in destination vector pICH47742 (Weber et al., 2011). PSAD, promoter of photosystem I reaction center subunit II (position A1-B2); respective FAX gene (position B3-B4); multiSTOP sequence (B5); RPL23ter: terminator of 50S ribosomal protein L23 (B6-C1).

Original Research

30 August 2022

Fatty acid export (FAX) proteins contribute to oil production in the green microalga Chlamydomonas reinhardtii

Janick Peter

, 6 more and

Katrin Philippar

10,806 views

7 citations

Overview of the chemical structures of bacterial and archaeal membrane lipids, including (A) different stereochemistry in the backbone being glycerol-3-phosphate (G3P) in bacteria and G1P in archaea (labeled in pink), and a different type of side chain (in yellow), i.e., fatty acids esterified to the G3P in bacteria, and isoprenoid alkyl chains linked through ether bonds to the G1P moiety in archaea. Polar headgroup is labeled in blue. (B) Different fatty acid side chains of phospholipid fatty acids (PLFA) commonly encountered in the bacterial membranes of piezophiles, with (B1) being C20:5, (B2) being (Z)-hexadec-9-enoic acid or palmitoleic acid, and (B3) being hexadecenoic acid or palmitic acid (C16), and their influence in the packing conformation and fluidity of the membrane. (C) Archaeal tetraether membrane lipids, being (C1) GDGT-4 with four cyclopentane moieties, and (C2) GDGT with no cyclopentane moieties (i.e., GDGT-0), and their impact on the conformation and fluidity of the membrane.

Review

06 January 2023

Microbial membrane lipid adaptations to high hydrostatic pressure in the marine environment

Anandi Tamby

, 1 more and

Laura Villanueva

3,898 views

4 citations

Effects of phospholipid head groups on the verapamil-stimulation of ATPase. (A) Lipid components of E. coli polar lipids, and (B) phospholipids found in mammalian plasma membranes. Purified Pgp was activated with 10 mM DTT and 1% POPC:POPE (50:50, w/w) lipid supplemented with indicated phospholipids as described in Experimental Procedures. Data points represent the mean ± SEM (n = 3). Kinetic parameters obtained from fits (solid lines) to the data points are listed in Table 2.

Original Research

23 February 2023

Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

Nghi N. B. Tran

, 4 more and

Ina L. Urbatsch

3,459 views

4 citations

Confocal microscopy analysis of the C-terminal domain of NaPi2b in ovarian carcinomas cells OVCAR-4 that were either alive (A–D) or fixed and permeabilized (E–H) and imaged in the Z-stacking mode. (A,E) Blue channel (Hoechst); (B,F) Red channel (PI); and (C,G) Green channel (Alexa Fluor 488), C-NaPi2b–mAbs D3V3I (Cell Signaling, United States) directed to the C-terminal domain of NaPi2b; (D,H) Merged Images; On the top (Y-axis and Z-axis combined) and right (X-axis and Z-axis combined) of each image, a composite image comprising of numerous photographs obtained at various focus distances is shown. White arrows indicate the position of NaPi2b on the cell membrane.

Brief Research Report

15 July 2022

Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells

Leisan Bulatova

, 6 more and

Ramziya Kiyamova

3,971 views

2 citations

Article Cover Image

Original Research

15 August 2022

Lipid/water interface of galactolipid bilayers in different lyotropic liquid-crystalline phases

Jakub Hryc

, 2 more and

Marta Pasenkiewicz-Gierula

3,008 views

3 citations

Mini Review

29 June 2022

Librational Dynamics of Spin-Labeled Membranes at Cryogenic Temperatures From Echo-Detected ED-EPR Spectra

Rosa Bartucci

and

Erika Aloi

1,417 views

0 citations

(A) Concentrations of lipid peroxidation products (MDA+4-HDA) in the homogenates of porcine tissues (thyroid, brain cortex, spleen, liver, kidney, and intestine), incubated with Fe2+ (9.375, 18.75, 37.5, 75, 150, 300, 600, 1,200, 1,800, 2,100, 2,400, 3,000, 3,600, 4,200, and 4,800 µM) + H2O2 (5 mM). *p < 0.05 vs. respective concentration in the thyroid. (B) Line graph representing concentrations of lipid peroxidation products (MDA+4-HDA) in the homogenates of porcine tissues (thyroid, brain cortex, spleen, liver, kidney, and intestine), incubated with Fe2+ (9.375, 18.75, 37.5, 75, 150, 300, 600, 1,200, 1,800, 2,100, 2,400, 3,000, 3,600, 4,200, and 4,800 µM) + H2O2 (5 mM). Vertical dashed lines indicate that iron concentration at which the LPO peak occurs for each individual tissue. Data points represent mean values of independent experiments analogically to results presented in Figure 3.

Original Research

03 June 2022

Membrane Lipids in the Thyroid Comparing to Those in Non-Endocrine Tissues Are Less Sensitive to Pro-Oxidative Effects of Fenton Reaction Substrates

Jan Stępniak

, 1 more and

Małgorzata Karbownik-Lewińska

1,629 views

6 citations

Perspective

27 May 2022

Current Knowledge on the Role of Cardiolipin Remodeling in the Context of Lipid Oxidation and Barth Syndrome

Zhuqing Liang

, 1 more and

Miriam L. Greenberg

2,686 views

5 citations

31P-NMR spectrum of M. galloprovincialis hemocytes raw extract.

Original Research

25 May 2022

Ceramide Aminoethylphosphonate as a New Molecular Target for Pore-Forming Aegerolysin-Based Protein Complexes

Teresa Balbi

, 7 more and

Kristina Sepčić

2,904 views

8 citations

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About

We are delighted to present the inaugural Frontiers in Molecular Biosciences –'Women in Lipids, Membranes, and Membranous Organelles’ article collection.

At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.

Therefore, Frontiers in Molecular Biosciences is proud to offer this platform to promote the work of women scientists, across all fields of Lipids, Membranes, and Membranous Organelles.

The work presented here highlights the diversity of research performed across the entire breadth of Lipids, Membranes, and Membranous Organelles research and presents advances in theory, experiment, and methodology with applications to compelling problems.

Please note: to be considered for this collection, at least one of the authors or co-authors should be a researcher who identifies as a woman.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

We are delighted to present the inaugural Frontiers in Molecular Biosciences –'Women in Lipids, Membranes, and Membranous Organelles’ article collection.

At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.

Therefore, Frontiers in Molecular Biosciences is proud to offer this platform to promote the work of women scientists, across all fields of Lipids, Membranes, and Membranous Organelles.

The work presented here highlights the diversity of research performed across the entire breadth of Lipids, Membranes, and Membranous Organelles research and presents advances in theory, experiment, and methodology with applications to compelling problems.

Please note: to be considered for this collection, at least one of the authors or co-authors should be a researcher who identifies as a woman.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Editors

Elena G Govorunova

University of Texas Health Science Center at Houston

Isabel María López-Lara

UNAM Campus Morelos, National Autonomous University of Mexico

Impact

41,073 Total views

31,931 Article views

7,491 Article downloads

1,651 Topic views

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Frontiers in Molecular Biosciences

Lipids, Membranes and Membranous Organelles

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