In the past decades obesity has been readdressed as a systemic disease with multiple organ and system involvement. The classic concept of the metabolic syndrome has evolved and numerous co-morbidities beyond cardio-vascular system have been witnessed, i.e., non-alcoholic fatty liver disease, autoimmune disorders, asthma, atopic dermatitis, chronic inflammatory conditions such as psoriasis, rheumatoid arthritis, and cancer. Obesity predisposes towards sub-clinical systemic inflammation, interacting with the control over autoimmunity and cancer.
Obesity is a chronic, metabolic, relapsing disease that requires long-term approach. It leads to many metabolic and other co-morbidities. The pathophysiology of obesity is related to chronic inflammation, disrupted appetite regulation, and gluco- and lipotoxicity. Obesity increases cardio-vascular risk which is very well documented in the scientific literature. There is a significant lack of understanding and following-up of other complications such as autoimmune disorders and skin alterations. Knowing the biological mechanisms of obesity could help us in preventing and treating its complications in a long-term basis. The goal is to summarize evidence-based recent advances in the field.
The aim of this Research Topic is to summarize state-of-the-art reviews covering different aspects of concept of obesity as a systemic disease, with sub-topics including:
- Obesity as a systemic disease
- Pathophysiology of the systemic involvement in obesity
- Inflammation in obesity
- Gut-brain axis in obesity
- Skin and obesity
- Autoimmune disorders and obesity
- Cancer and obesity
- Precision and personalized management of obesity
In the past decades obesity has been readdressed as a systemic disease with multiple organ and system involvement. The classic concept of the metabolic syndrome has evolved and numerous co-morbidities beyond cardio-vascular system have been witnessed, i.e., non-alcoholic fatty liver disease, autoimmune disorders, asthma, atopic dermatitis, chronic inflammatory conditions such as psoriasis, rheumatoid arthritis, and cancer. Obesity predisposes towards sub-clinical systemic inflammation, interacting with the control over autoimmunity and cancer.
Obesity is a chronic, metabolic, relapsing disease that requires long-term approach. It leads to many metabolic and other co-morbidities. The pathophysiology of obesity is related to chronic inflammation, disrupted appetite regulation, and gluco- and lipotoxicity. Obesity increases cardio-vascular risk which is very well documented in the scientific literature. There is a significant lack of understanding and following-up of other complications such as autoimmune disorders and skin alterations. Knowing the biological mechanisms of obesity could help us in preventing and treating its complications in a long-term basis. The goal is to summarize evidence-based recent advances in the field.
The aim of this Research Topic is to summarize state-of-the-art reviews covering different aspects of concept of obesity as a systemic disease, with sub-topics including:
- Obesity as a systemic disease
- Pathophysiology of the systemic involvement in obesity
- Inflammation in obesity
- Gut-brain axis in obesity
- Skin and obesity
- Autoimmune disorders and obesity
- Cancer and obesity
- Precision and personalized management of obesity