Towards an Understanding of Tinnitus Heterogeneity, Volume II

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Editorial

12 February 2024

Editorial: Towards an understanding of tinnitus heterogeneity, volume II

Christopher R. Cederroth

,

Tobias Kleinjung

,

Berthold Langguth

,

Arnaud Noreña

, 3 more and

Winfried Schlee

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This Research Topic is part of the article collection series: Towards an Understanding of Tinnitus Heterogeneity.

Tinnitus is the perception of a sound when no external sound is present. The severity of tinnitus varies but it can be debilitating for many patients. With more than 100 million people with chronic tinnitus worldwide, tinnitus is a disorder of high prevalence.

The increased knowledge in the neuroscience of tinnitus has led to the emergence of promising treatment approaches, but no uniformly effective treatment for tinnitus has been identified. The large patient heterogeneity is considered to be the major obstacle for the development of effective treatment strategies against tinnitus.

This Frontiers research topic aims to provide an inter- and multi-disciplinary survey of cutting-edge research in tinnitus, in order to better understand tinnitus heterogeneity and improve therapeutic outcomes. This requires the coordinated effort of multiple scientific disciplines including neuroscience, neurology, genetics, audiology, otolaryngology, psychology, psychiatry, pharmacology, epidemiology, medical informatics, data mining and statistics.

We welcome all forms of submissions: Original Research Articles, Review Articles, Method Articles, Clinical Trials, Case Reports, Mini Review Articles, Code, Book Reviews, General Commentaries, Perspectives, Hypotheses & Theories.

The aim of the topic is to address, in humans and animals, key questions about tinnitus heterogeneity, including:
• Neural correlates and large-scale brain connectivity: What is the neurobiological mechanisms of the different forms of tinnitus? What neuroimaging methods should be used for the classification of tinnitus. What neuronal mechanisms are general to all forms of tinnitus or specific to subtypes?
• Impact of emotional states on tinnitus severity: How do stress and emotional states influence the vulnerability to develop tinnitus or to increase its intensity? What are the neural circuits mediating these effects? What are the mechanisms underlying the emotional influence on tinnitus generation and persistence?
• Genetic basis to tinnitus: There is a lack of evidence for the contribution of genetics on tinnitus generation, or vulnerability to develop tinnitus. What is the heritability of tinnitus? What are the forms of tinnitus with the greatest genetic influence and how is it affecting the brain? What genes and variants are associated with specific forms of tinnitus? What is the role of epigenetic changes in tinnitus development?
• Developing new methods: How can we use the most recent technological advances for the research and treatment of tinnitus? How can we take advantage of modern data mining techniques to better understand the heterogeneity of tinnitus?
• Consensus of methods: In both animal and human studies, there is a wide variety of methods and protocols to assess tinnitus, which - in absence of consensus - led to divergent results. What methodologies or protocols should emerge? These could include standards for neuroimaging as well as clinical assessment, measuring treatment outcomes, audiological assessment and genetics.
• Clinical studies for specific types of tinnitus: Given the large heterogeneity in tinnitus, there is probably not a one-therapy-fits-all approach possible. What therapy works for which type of patients?
• State of the field and future challenges: What is the current consensus on tinnitus subtyping? What is the most fruitful avenue for tinnitus research?

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Editors

Deborah A Hall

Heriot-Watt University Malaysia

Birgit Mazurek

Charité University Medicine Berlin

Arnaud Norena

Aix-Marseille Université

Grant Searchfield

The University of Auckland

Sven Vanneste

Trinity College Dublin

Berthold Langguth

University of Regensburg

Tobias Kleinjung

University of Zurich

Nathan Weisz

University of Salzburg

Myra Spiliopoulou

Otto von Guericke University Magdeburg

Patrick K.A. Neff

University of Zurich

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177,235 Total views

143,506 Article views

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6,834 Topic views

Published In

Frontiers in Aging Neuroscience

Neuroinflammation and Neuropathy

Frontiers in Psychology

Auditory Cognitive Neuroscience, Perception Science

Frontiers in Neurology

Neuro-Otology, Autonomic Neuroscience

Frontiers in Physiology

Autonomic Neuroscience

Frontiers in Neuroscience

Perception Science, Auditory Cognitive Neuroscience, Autonomic Neuroscience

Frontiers in Cellular Neuroscience

Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

Frontiers in Behavioral Neuroscience

Emotion Regulation and Processing, Pathological Conditions

Frontiers in Human Neuroscience

Brain Health and Clinical Neuroscience

Frontiers in Integrative Neuroscience

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