The process of nociception is the perception of noxious stimuli (chemical, thermal or mechanical) through the peripheral and central nervous system by neurons of the nociceptive system. These neurons are found in the dorsal root ganglia (DRG) or the trigeminal ganglia and project to the brainstem, spinal dorsal horn, and peripherally to the skin and other organs. The encoding of these stimuli allows us to detect pain and aids to our survival and the avoidance of potentially dangerous stimuli. The molecular processes involved in the nociception and the development of the sensory neurons are of great interest to better understand nociception in pathological contexts such as nociceptive pain, neuropathic pain, inflammatory pain, and congenital insensitivity to pain (CIP).
This Research Topic aims to investigate and highlight key molecules and pathways involved in the development of the nociceptive system and how their dysregulation is implicated in aberrant nociception. The nociceptors involved in nociception will depend on the type of perceived stimuli such as cold, hot, mechanical perception, or a wide variety of chemical stimuli. This diversity contributes to the complexity of understanding pathological nociception and the challenge of developing effective treatments. Understanding which molecular and signaling pathways are involved in nociception will enable us to investigate potential therapeutic targets to help pain management and treat chronic pain.
This Topic welcomes, and is not limited to, original research, reviews, systematic reviews, perspectives on:
• The development of sensory neurons
• The molecular pathways involved in normal and pathological nociception and nociceptive responses
• The molecular pathways involved in the detection of potentially painful chemical, mechanical and thermal stimuli
• Potential therapeutic targets for pain treatment
• Studies investigating the molecular pathways involved in congenital insensitivity to pain.
The process of nociception is the perception of noxious stimuli (chemical, thermal or mechanical) through the peripheral and central nervous system by neurons of the nociceptive system. These neurons are found in the dorsal root ganglia (DRG) or the trigeminal ganglia and project to the brainstem, spinal dorsal horn, and peripherally to the skin and other organs. The encoding of these stimuli allows us to detect pain and aids to our survival and the avoidance of potentially dangerous stimuli. The molecular processes involved in the nociception and the development of the sensory neurons are of great interest to better understand nociception in pathological contexts such as nociceptive pain, neuropathic pain, inflammatory pain, and congenital insensitivity to pain (CIP).
This Research Topic aims to investigate and highlight key molecules and pathways involved in the development of the nociceptive system and how their dysregulation is implicated in aberrant nociception. The nociceptors involved in nociception will depend on the type of perceived stimuli such as cold, hot, mechanical perception, or a wide variety of chemical stimuli. This diversity contributes to the complexity of understanding pathological nociception and the challenge of developing effective treatments. Understanding which molecular and signaling pathways are involved in nociception will enable us to investigate potential therapeutic targets to help pain management and treat chronic pain.
This Topic welcomes, and is not limited to, original research, reviews, systematic reviews, perspectives on:
• The development of sensory neurons
• The molecular pathways involved in normal and pathological nociception and nociceptive responses
• The molecular pathways involved in the detection of potentially painful chemical, mechanical and thermal stimuli
• Potential therapeutic targets for pain treatment
• Studies investigating the molecular pathways involved in congenital insensitivity to pain.