Regulatory B (Breg) cells population is an important modulatory component of the immune system that maintains immune homeostasis, suppresses excessive inflammation, and prevents autoimmunity. To inhibit inflammation, Breg cells produce anti-inflammatory cytokines (IL-10, TGF-? and IL-35), induce death ligand-mediated apoptosis, suppress the differentiation, activation, and proliferation of effector T lymphocytes by direct cell-cell interactions and/or by the alteration of the immune microenvironment, and increase the frequency of regulatory T cells. The immunomodulatory properties of Breg cells can be observed in various pathological conditions (chronic inflammatory disease, infection, autoimmune disease, after transplantation, and cancers). They can also be used by pathogenic bacteria and cancer cells to evade the immune system.
Over the last time, our understanding of the immunobiology of Breg cells in health and disease has improved considerably. However, there remains much to be understood with respect to the development, function, and contribution of Breg cells in gastrointestinal diseases and their therapeutic potential.
In this Research Topic, we welcome the submission of Original Research, Review, Mini review, and Perspective articles highlighting several important aspects of Breg cells in gastrointestinal diseases. Topic areas of interest include but are not limited to:
- The role of Breg cells in the pathogenesis of gastrointestinal diseases.
- Breg cell stability, phenotype, differentiation, and functions in gastrointestinal diseases
- Breg cell contribution and their new mechanisms to impairment of immune system activation
- Breg cell contribution and their mechanisms to activation of other regulatory cells
- Infiltrating Breg cells relative to their peripheral counterparts in gastrointestinal diseases
- Molecular signatures of Breg cell in gastrointestinal diseases
- Preclinical and clinical studies where Breg cell are used to treat gastrointestinal diseases
- Modified Breg cell therapies in gastrointestinal diseases.
Regulatory B (Breg) cells population is an important modulatory component of the immune system that maintains immune homeostasis, suppresses excessive inflammation, and prevents autoimmunity. To inhibit inflammation, Breg cells produce anti-inflammatory cytokines (IL-10, TGF-? and IL-35), induce death ligand-mediated apoptosis, suppress the differentiation, activation, and proliferation of effector T lymphocytes by direct cell-cell interactions and/or by the alteration of the immune microenvironment, and increase the frequency of regulatory T cells. The immunomodulatory properties of Breg cells can be observed in various pathological conditions (chronic inflammatory disease, infection, autoimmune disease, after transplantation, and cancers). They can also be used by pathogenic bacteria and cancer cells to evade the immune system.
Over the last time, our understanding of the immunobiology of Breg cells in health and disease has improved considerably. However, there remains much to be understood with respect to the development, function, and contribution of Breg cells in gastrointestinal diseases and their therapeutic potential.
In this Research Topic, we welcome the submission of Original Research, Review, Mini review, and Perspective articles highlighting several important aspects of Breg cells in gastrointestinal diseases. Topic areas of interest include but are not limited to:
- The role of Breg cells in the pathogenesis of gastrointestinal diseases.
- Breg cell stability, phenotype, differentiation, and functions in gastrointestinal diseases
- Breg cell contribution and their new mechanisms to impairment of immune system activation
- Breg cell contribution and their mechanisms to activation of other regulatory cells
- Infiltrating Breg cells relative to their peripheral counterparts in gastrointestinal diseases
- Molecular signatures of Breg cell in gastrointestinal diseases
- Preclinical and clinical studies where Breg cell are used to treat gastrointestinal diseases
- Modified Breg cell therapies in gastrointestinal diseases.
