Cerebral microdialysis (CMD) is a technique that has been used since the 1970s to sample the extracellular fluid in the brain. Initially used in the laboratory, it gained clinical use in the 1990s when the tools for analyzing the products of brain metabolism in the interstitial fluid became readily available. The small molecules (glucose, lactate, pyruvate, aspartate, glutamate, glycerol) are particularly reflective of the neuronal metabolism/injury in both normal and pathologic conditions. A better understanding of the changes that occur for example in traumatic brain injury provides guidance for adopting therapies to optimize the brain environment. CMD is used in conjunction with other brain multimodal monitors (ie. Brain pressure, brain oxygenation, cerebral blood flow) to provide a more complete picture about brain metabolism and perfusion/oxygenation.
The aim of this Research Topic is to tackle the need for increased awareness of cerebral microdialysis:
1. What has been done and what is known
2. Current clinical applications
3. Data for clinical utility
4. Current research (including laboratory or animal studies) and clinical implications
5. Why is cerebral microdialysis not widely used?
We aim to review the current state of the art for cerebral microdialysis both in research and in clinical applications. We invite contributions from the pioneers and developers of cerebral microdialysis, and from those who are currently using cerebral microdialysis in the lab and clinically.
We welcome submissions of Original Research, Reviews, Clinical studies and Meta-analysis including but not limited to:
• Historical development and key studies in cerebral microdialysis
• Clinical applications in Traumatic Brain Injury and Stroke in adults and pediatrics
• Other clinical applications (ie. Brain tumors, dementia studies)
• Laboratory research studies with clinical implications
• Cerebral microdialysis as a marker of cerebral edema or the glymphatics
• Studies describing the integration of cerebral microdialysis into multimodal brain monitoring-challenges and pitfalls
• The “nuts and bolts” of cerebral microdialysis from the implantation of the catheters to the analysis of the analytes
• Cerebral microdialysis instrumentation and challenges
• New innovations in clinical cerebral microdialysis (ie. Loke system)
• Cost analysis studies of cerebral microdialysis
• Future prospects for cerebral microdialysis
Cerebral microdialysis (CMD) is a technique that has been used since the 1970s to sample the extracellular fluid in the brain. Initially used in the laboratory, it gained clinical use in the 1990s when the tools for analyzing the products of brain metabolism in the interstitial fluid became readily available. The small molecules (glucose, lactate, pyruvate, aspartate, glutamate, glycerol) are particularly reflective of the neuronal metabolism/injury in both normal and pathologic conditions. A better understanding of the changes that occur for example in traumatic brain injury provides guidance for adopting therapies to optimize the brain environment. CMD is used in conjunction with other brain multimodal monitors (ie. Brain pressure, brain oxygenation, cerebral blood flow) to provide a more complete picture about brain metabolism and perfusion/oxygenation.
The aim of this Research Topic is to tackle the need for increased awareness of cerebral microdialysis:
1. What has been done and what is known
2. Current clinical applications
3. Data for clinical utility
4. Current research (including laboratory or animal studies) and clinical implications
5. Why is cerebral microdialysis not widely used?
We aim to review the current state of the art for cerebral microdialysis both in research and in clinical applications. We invite contributions from the pioneers and developers of cerebral microdialysis, and from those who are currently using cerebral microdialysis in the lab and clinically.
We welcome submissions of Original Research, Reviews, Clinical studies and Meta-analysis including but not limited to:
• Historical development and key studies in cerebral microdialysis
• Clinical applications in Traumatic Brain Injury and Stroke in adults and pediatrics
• Other clinical applications (ie. Brain tumors, dementia studies)
• Laboratory research studies with clinical implications
• Cerebral microdialysis as a marker of cerebral edema or the glymphatics
• Studies describing the integration of cerebral microdialysis into multimodal brain monitoring-challenges and pitfalls
• The “nuts and bolts” of cerebral microdialysis from the implantation of the catheters to the analysis of the analytes
• Cerebral microdialysis instrumentation and challenges
• New innovations in clinical cerebral microdialysis (ie. Loke system)
• Cost analysis studies of cerebral microdialysis
• Future prospects for cerebral microdialysis