Bone Cell Differentiation in Health and Disease

Editorial

16 December 2022

Editorial: Bone cell differentiation in health and disease

Michaela Tencerova

and

Chandi C. Mandal

1,083 views

0 citations

Editors

Chandi C Mandal

Central University of Rajasthan

Michaela Tencerova

Institute of Physiology, Academy of Sciences of the Czech Republic (ASCR)

Impact

Original Research

19 May 2022

Super-Enhancer-Associated Long Non-Coding RNA LINC01485 Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Regulating MiR-619-5p/RUNX2 Axis

Wenli Gu

, 8 more and

Jianjiang Zhao

2,967 views

6 citations

Original Research

12 September 2022

Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus

Elliot Ballato

, 7 more and

Reina Armamento-Villareal

3,226 views

2 citations

Original Research

25 August 2022

Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs

L. Henry Goodnough

, 9 more and

Charles K. F. Chan

2,483 views

3 citations

Original Research

17 October 2022

Aberrant activation of TGF-β1 induces high bone turnover via Rho GTPases-mediated cytoskeletal remodeling in Camurati-Engelmann disease

Qi Chen

, 11 more and

Fangfang Liu

2,391 views

2 citations

Original Research

22 February 2022

Melatonin Accelerates Osteoporotic Bone Defect Repair by Promoting Osteogenesis–Angiogenesis Coupling

Sheng Zheng

, 5 more and

Yikai Li

9,203 views

34 citations

Original Research

15 December 2021

Liraglutide Inhibits Osteoclastogenesis and Improves Bone Loss by Downregulating Trem2 in Female Type 1 Diabetic Mice: Findings From Transcriptomics

Jie Yu

, 7 more and

Yu-Xiu Li

4,384 views

12 citations

Original Research

02 December 2021

The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression

Ding Li

, 3 more and

Yu Xia

2,944 views

8 citations

Original Research

24 September 2021

Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling Pathways

Mengbo Zhu

, 11 more and

Shaowei Wang

2,971 views

15 citations

Comparison of the expression of the AGER, and BAX/BCL2 ratio between PBMC-isolated from subjects with diabetes with preserved osteogenic differentiation potential (DM-pD) and PBMC-isolated from diabetics with impaired osteogenic differentiation potential (DM-iD) by using age- and pentosidine-matched PBMC-isolated from non-diabetics with preserved osteogenic differentiation (NDM-pD) as a reference group. DM-iD showed higher expression of AGER and BAX/BCL2 ratio than the reference by 6.6 and 5.0 times, respectively, while DM-pD showed similar expression of AGER and BAX/BCL2 ratio to the reference. The expression of AGER and BAX/BCL2 ratio in DM-iD was significantly higher than that in DM-pD.

Original Research

26 August 2021

Age-Influenced Receptors of Advanced Glycation End Product Overexpression Associated With Osteogenic Differentiation Impairment in Patients With Type 2 Diabetes

Mattabhorn Phimphilai

, 1 more and

Prachya Kongtawelert

2,630 views

8 citations

(A) Wild-type (WT) and Ncam–/– (KO) MSCs were examined with anti-NCAM antibody. β-actin was detected as a loading control. The expression of RunX2 (B) and Osterix (C) was analysed by real-time PCR (The data are expressed as the mean ± SEM of three independent experiments. ***p < 0.001, compared with WT MSCs). (D) The expression of RunX2 and Osterix was analysed by immunoblotting, β-actin was detected as a loading control. Levels of RunX2 (E) and Osterix (F) were quantified by densitometry and normalized to β-actin (Data are representative of three independent experiments and values are means ± SEM. **p < 0.01, ***p < 0.001, compared with WT MSCs). (G) Calcium deposition of differentiated WT and KO MSCs was assessed by Alizarin red staining. (H) The Alizarin red staining was extracted and quantified, the wavelength was measured at 562 nm (Data are representative of three independent experiments and values are means ± SEM. ***p < 0.001, compared with WT MSCs).

Original Research

12 May 2021

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Bin-Feng Cheng

, 8 more and

Hai-Jie Yang

4,050 views

14 citations

Open for submission

Frontiers in Endocrinology

Genetic and Molecular Determinants in Bone Health and Diseases, volume II

Edited by Michela Rossi, Andrea Del Fattore, Gretl Hendrickx, Sher Poudel

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25 October 2024

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