With the development of regenerative medicine, tissue repair of diseases has continued to improve at the molecular, cellular, tissue and organ levels. As the core of tissue repair, seed cells are widely used in various fields of regenerative medicine. Pulp stem cells derived from neural spines show low immunogenicity and are easily obtained from deciduous teeth, extracted orthodontic teeth or third molars without ethical problems and are promising in regenerative medicine.
Meanwhile, paracrine action of cells, especially the secretion of stem cell-derived exosomes, plays an important role in cellular communication, immune response, angiogenesis, scar formation, tissue repair and other biological functions. As a nanoscale extracellular vesicle, exosomes contain bioactive molecules, such as RNA and proteins, which can act as nanocarriers to deliver active factors or small molecules and promote tissue repair. The favorable biological properties of exosomes include biocompatibility, stability, low toxicity and proficient exchange of molecular carriers, making exosomes a prime candidate for tissue engineering and regenerative medicine. Preclinical studies with exosomes have been performed in the areas of bone/cartilage repair, nerve regeneration, liver and kidney regeneration, skin repair, vascular tissue regeneration, etc.
Despite the promising results achieved with dental pulp stem cells and related exosomes, there remains the question of how to deliver and release them effectively and persistently into the subject tissue. Thus, exploring dental pulp stem cells, exosomes and related delivery systems could facilitate tissue regeneration therapies and provide insights into regenerative medicine.
While the effects of stem cells/exosomes on tissue regeneration are promising, it is also important to understand the "how" and "why". In-depth and advanced research into the uses and mechanisms of stem cells, exosomes and related delivery systems will accelerate progress in tissue regeneration and minimize the gap between experimental results and clinical applications. There are several strategies along this direction.
1) How to deliver stem cells or exosomes (e.g., nano-delivery systems) to achieve the target on the subject tissue.
2) How to release stem cells or exosomes (e.g., biodegradable or highly porous hydrogels, plasmids, and proteins) to promote efficacy rather than rapid biodegradation.
3) To investigate the local and systemic use of stem cells or exosomes in tissues for more optimal applications; and
4) Conduct clinical trials on the therapeutic efficacy and safety of stem cells, exosomes and related adjuvant materials for high-quality clinical translation.
This research topic is dedicated to presenting recent advances in dental pulp stem cells, exosomes, and related delivery systems to achieve a durable and efficient ability for tissue repair leading to successful regeneration. Research papers and reviews are of interest.
In particular, topics to be discussed include, but are not limited to:
1. How to deliver dental pulp stem cells or exosomes (e.g., nano delivery systems) to target recipient tissues.
2. How to release dental pulp stem cells or exosomes (e.g., biodegradable or highly porous hydrogels, plasmids, and proteins) to promote efficacy without rapid biodegradation.
3. Local/systemic use of dental stem cells or exosomes on tissues for more optimal application.
4. Clinical trials on the therapeutic efficacy and safety of dental pulp stem cells, exosomes and related adjuvant materials for high-quality clinical translation.
With the development of regenerative medicine, tissue repair of diseases has continued to improve at the molecular, cellular, tissue and organ levels. As the core of tissue repair, seed cells are widely used in various fields of regenerative medicine. Pulp stem cells derived from neural spines show low immunogenicity and are easily obtained from deciduous teeth, extracted orthodontic teeth or third molars without ethical problems and are promising in regenerative medicine.
Meanwhile, paracrine action of cells, especially the secretion of stem cell-derived exosomes, plays an important role in cellular communication, immune response, angiogenesis, scar formation, tissue repair and other biological functions. As a nanoscale extracellular vesicle, exosomes contain bioactive molecules, such as RNA and proteins, which can act as nanocarriers to deliver active factors or small molecules and promote tissue repair. The favorable biological properties of exosomes include biocompatibility, stability, low toxicity and proficient exchange of molecular carriers, making exosomes a prime candidate for tissue engineering and regenerative medicine. Preclinical studies with exosomes have been performed in the areas of bone/cartilage repair, nerve regeneration, liver and kidney regeneration, skin repair, vascular tissue regeneration, etc.
Despite the promising results achieved with dental pulp stem cells and related exosomes, there remains the question of how to deliver and release them effectively and persistently into the subject tissue. Thus, exploring dental pulp stem cells, exosomes and related delivery systems could facilitate tissue regeneration therapies and provide insights into regenerative medicine.
While the effects of stem cells/exosomes on tissue regeneration are promising, it is also important to understand the "how" and "why". In-depth and advanced research into the uses and mechanisms of stem cells, exosomes and related delivery systems will accelerate progress in tissue regeneration and minimize the gap between experimental results and clinical applications. There are several strategies along this direction.
1) How to deliver stem cells or exosomes (e.g., nano-delivery systems) to achieve the target on the subject tissue.
2) How to release stem cells or exosomes (e.g., biodegradable or highly porous hydrogels, plasmids, and proteins) to promote efficacy rather than rapid biodegradation.
3) To investigate the local and systemic use of stem cells or exosomes in tissues for more optimal applications; and
4) Conduct clinical trials on the therapeutic efficacy and safety of stem cells, exosomes and related adjuvant materials for high-quality clinical translation.
This research topic is dedicated to presenting recent advances in dental pulp stem cells, exosomes, and related delivery systems to achieve a durable and efficient ability for tissue repair leading to successful regeneration. Research papers and reviews are of interest.
In particular, topics to be discussed include, but are not limited to:
1. How to deliver dental pulp stem cells or exosomes (e.g., nano delivery systems) to target recipient tissues.
2. How to release dental pulp stem cells or exosomes (e.g., biodegradable or highly porous hydrogels, plasmids, and proteins) to promote efficacy without rapid biodegradation.
3. Local/systemic use of dental stem cells or exosomes on tissues for more optimal application.
4. Clinical trials on the therapeutic efficacy and safety of dental pulp stem cells, exosomes and related adjuvant materials for high-quality clinical translation.