The vertebrate limb has arguably served as one of the best model systems to further our understanding of mechanisms underpinning organ formation over a long period of time. Its experimental accessibility and anatomical visibility made it a highly favored system, relative to other organs, to test novel concepts and gain new insights. These features in turn laid a ground work that has been exploited at a molecular level in the modern era of genetics. Yet, there are major gaps in our understanding of limb morphogenesis; what physiological or epigenetic factors regulate limb development, what explains the different number of digits across species, how fins were transited to limbs, how the limb cells keep positional information during regeneration, and why limb regenerative capability differs between species, to name a few. These are just examples, there still are many gaps in the picture of how the vertebrate limbs form and are diversified, not fully explained by classical transcriptional regulation and morphogenic signaling.
The underlying motivation for this Research Topic is to address the current gaps in knowledge by representing recent advances in limb morphogenesis. This collection focuses on studies using state-of-the-art technology that bring new insights into vertebrate limb morphogenesis, particularly limb development, evo-devo, and regeneration.
Potential topics include, but are not limited to:
-Single cell transcriptome in limb development, evolution, and regeneration
-Epigenetic regulation in limb development, evolution, and regeneration
-Self organizing mechanisms in limb development and regeneration
-Positional information in limb development and regeneration
-Mechano-biology in limb development
-Bioelectric signaling in limb development and regeneration
-Quantitative imaging in limb development and regeneration
-Mathematical modeling in limb development and evolution
-Programmed cell death in limb development and evolution
-Derivation of limb progenitors from pluripotent stem cells
-Limb evo-devo; fin-to-limb transition
The vertebrate limb has arguably served as one of the best model systems to further our understanding of mechanisms underpinning organ formation over a long period of time. Its experimental accessibility and anatomical visibility made it a highly favored system, relative to other organs, to test novel concepts and gain new insights. These features in turn laid a ground work that has been exploited at a molecular level in the modern era of genetics. Yet, there are major gaps in our understanding of limb morphogenesis; what physiological or epigenetic factors regulate limb development, what explains the different number of digits across species, how fins were transited to limbs, how the limb cells keep positional information during regeneration, and why limb regenerative capability differs between species, to name a few. These are just examples, there still are many gaps in the picture of how the vertebrate limbs form and are diversified, not fully explained by classical transcriptional regulation and morphogenic signaling.
The underlying motivation for this Research Topic is to address the current gaps in knowledge by representing recent advances in limb morphogenesis. This collection focuses on studies using state-of-the-art technology that bring new insights into vertebrate limb morphogenesis, particularly limb development, evo-devo, and regeneration.
Potential topics include, but are not limited to:
-Single cell transcriptome in limb development, evolution, and regeneration
-Epigenetic regulation in limb development, evolution, and regeneration
-Self organizing mechanisms in limb development and regeneration
-Positional information in limb development and regeneration
-Mechano-biology in limb development
-Bioelectric signaling in limb development and regeneration
-Quantitative imaging in limb development and regeneration
-Mathematical modeling in limb development and evolution
-Programmed cell death in limb development and evolution
-Derivation of limb progenitors from pluripotent stem cells
-Limb evo-devo; fin-to-limb transition