The nervous system is composed of two parts, the central nervous system (CNS) and the peripheral nervous system (PNS), both playing a leading role in regulating function activities in the body. We are now aware that many important organs perform a large variety of functions under the control of the nervous systems, but how these processes are coordinated is poorly understood. Indeed, with the rapid development of visual virus tracing technology, a growing body of research is currently being done in visceral-cerebral neuroanatomy. The close anatomical connections between the CNS and other internal organs, such as the heart, kidney, lung, bladder, liver, gut, and spleen, are starting to be understood, offering a foundation for the crosstalk between CNS and other systems., The enteric nervous system (ENS), termed the second brain, has “independent thinking” without assistance from the CNS, and it also closely interacts with other systems, such as the immune system.
The intriguing concept of crosstalk implies bilateral communication, including passing information and feedback to and from the nervous and other systems. This bidirectional interaction needs distinct neural circuits to map into, working as complex connections conducting specific information in the nervous system. It is worth exploring these signals with accurate methods, in pathological or physiological conditions. The Omics, ranging from Genomics, Proteomics, Metabolomics, Transcriptomics, and RNomics have considerable potentialities in this field.
Elucidating the interactions of the nervous systems with different systems or organs contributes to understanding the body's regulatory mechanism from a holistic perspective.
Thus, this Research Topic explores promising research trends in crosstalk between nervous systems and other body systems. We are looking forward to submissions in the form of Original Research, Translational Studies, Clinical Trials, and Reviews focused on, but not limited to, the following subtopics:
• Composition and functionality of the nervous network connection between nervous systems and other body systems.
• Identification and characterization of the novel medium in information exchange between the nervous system and other body systems, including circulating DNAs, extracellular RNAs, extracellular vesicles, etc.
• Functional neurotransmitter-based crosstalk between nervous systems and other body systems in pathophysiological conditions.
• Multiomics, such as the Transcriptome, Proteome, and Metabolome, reveals the characteristics of different cell types in the nervous system and the reflection of the crosstalk between nervous systems and other body systems.
• Novel therapeutic insights to treat nervous and other body systems diseases in translational medical research, such as Nano-targeted drug delivery.
• New technologies related to exploring the crosstalk between nervous systems and other body systems.
• Mechanisms and related basic and clinical researches of neuromodulation in the treatment of body system diseases.
The nervous system is composed of two parts, the central nervous system (CNS) and the peripheral nervous system (PNS), both playing a leading role in regulating function activities in the body. We are now aware that many important organs perform a large variety of functions under the control of the nervous systems, but how these processes are coordinated is poorly understood. Indeed, with the rapid development of visual virus tracing technology, a growing body of research is currently being done in visceral-cerebral neuroanatomy. The close anatomical connections between the CNS and other internal organs, such as the heart, kidney, lung, bladder, liver, gut, and spleen, are starting to be understood, offering a foundation for the crosstalk between CNS and other systems., The enteric nervous system (ENS), termed the second brain, has “independent thinking” without assistance from the CNS, and it also closely interacts with other systems, such as the immune system.
The intriguing concept of crosstalk implies bilateral communication, including passing information and feedback to and from the nervous and other systems. This bidirectional interaction needs distinct neural circuits to map into, working as complex connections conducting specific information in the nervous system. It is worth exploring these signals with accurate methods, in pathological or physiological conditions. The Omics, ranging from Genomics, Proteomics, Metabolomics, Transcriptomics, and RNomics have considerable potentialities in this field.
Elucidating the interactions of the nervous systems with different systems or organs contributes to understanding the body's regulatory mechanism from a holistic perspective.
Thus, this Research Topic explores promising research trends in crosstalk between nervous systems and other body systems. We are looking forward to submissions in the form of Original Research, Translational Studies, Clinical Trials, and Reviews focused on, but not limited to, the following subtopics:
• Composition and functionality of the nervous network connection between nervous systems and other body systems.
• Identification and characterization of the novel medium in information exchange between the nervous system and other body systems, including circulating DNAs, extracellular RNAs, extracellular vesicles, etc.
• Functional neurotransmitter-based crosstalk between nervous systems and other body systems in pathophysiological conditions.
• Multiomics, such as the Transcriptome, Proteome, and Metabolome, reveals the characteristics of different cell types in the nervous system and the reflection of the crosstalk between nervous systems and other body systems.
• Novel therapeutic insights to treat nervous and other body systems diseases in translational medical research, such as Nano-targeted drug delivery.
• New technologies related to exploring the crosstalk between nervous systems and other body systems.
• Mechanisms and related basic and clinical researches of neuromodulation in the treatment of body system diseases.
