Peripheral nerve injury (PNI) or spinal cord injury (SCI) can result in a loss of sensory, motor, or autonomic nerve functions. It could be a devastating event for patients and their families, both physically and psychologically. Peripheral nerve regeneration and spinal cord injury repair are both complex processes involving numerous physiological or pathological mechanisms. Recently, an increasing number of methods for promoting neural repair and regeneration have been discovered. Among them, extracellular vesicles (EVs) derived from living cells have drawn the great attention of researchers and clinicians due to their bioregulatory capabilities and distinct physiochemical characteristics. These nano-sized biological vesicles have been shown to govern various physiological and pathological activities in repair or regeneration processes, such as cell viability, proliferation, migration and differentiation, all of which have a significant impact on an individual’s recovery outcome after PNI or SCI. EVs have been biomedically engineered to further improve their therapeutic effect in the treatment of PNI or SCI, which may be a promising strategy for nerve repair or regeneration.
This Research Topic focuses on recent advances in promoting nerve repair by using utilizing natural or engineered EVs that play essential biological functions in neural regeneration, at both cellular and molecular levels.
We welcome all manuscripts in the form of Original Research Articles, Reviews, Perspectives, or Brief research reports, including but not limited to:
- Study the role of EVs in promoting nerve repair or regeneration using physical stimulations, such as electrical stimulus, magnetic force, ultrasound, and so on.
- Explore cellular and molecular mechanisms of functionalized EVs on neurons or glial cells under pathological conditions.
- Investigate the therapeutic potential of genetically modified- or biochemically engineered- EVs in neuroregeneration after PNI or SCI.
- Analyze cell communication and signal transduction pathway of EVs in the neuroregeneration.
- Examine the neuroprotective effect of EVs on neurons and glial cells after nerve injury.
Peripheral nerve injury (PNI) or spinal cord injury (SCI) can result in a loss of sensory, motor, or autonomic nerve functions. It could be a devastating event for patients and their families, both physically and psychologically. Peripheral nerve regeneration and spinal cord injury repair are both complex processes involving numerous physiological or pathological mechanisms. Recently, an increasing number of methods for promoting neural repair and regeneration have been discovered. Among them, extracellular vesicles (EVs) derived from living cells have drawn the great attention of researchers and clinicians due to their bioregulatory capabilities and distinct physiochemical characteristics. These nano-sized biological vesicles have been shown to govern various physiological and pathological activities in repair or regeneration processes, such as cell viability, proliferation, migration and differentiation, all of which have a significant impact on an individual’s recovery outcome after PNI or SCI. EVs have been biomedically engineered to further improve their therapeutic effect in the treatment of PNI or SCI, which may be a promising strategy for nerve repair or regeneration.
This Research Topic focuses on recent advances in promoting nerve repair by using utilizing natural or engineered EVs that play essential biological functions in neural regeneration, at both cellular and molecular levels.
We welcome all manuscripts in the form of Original Research Articles, Reviews, Perspectives, or Brief research reports, including but not limited to:
- Study the role of EVs in promoting nerve repair or regeneration using physical stimulations, such as electrical stimulus, magnetic force, ultrasound, and so on.
- Explore cellular and molecular mechanisms of functionalized EVs on neurons or glial cells under pathological conditions.
- Investigate the therapeutic potential of genetically modified- or biochemically engineered- EVs in neuroregeneration after PNI or SCI.
- Analyze cell communication and signal transduction pathway of EVs in the neuroregeneration.
- Examine the neuroprotective effect of EVs on neurons and glial cells after nerve injury.