Metabolic diseases such as obesity and diabetes cause disruption of systemic energy metabolism and is a major public health problem with at least 2 billion people worldwide. By contrast, skeletal muscle tissue makes a substantial contribution to promoting energy efficiency because it remodels cellular size, composition, and function in response to a variety of nutritional changes. However, metabolic diseases can dynamically affect the quantity and quality of skeletal muscle, including decreased contractile function, impaired insulin sensitivity, muscle atrophy, and cellular stress. A deeper understanding of myopathology in metabolic disorders could provide clues to therapeutic strategies.
The aim of this Research Topic is to highlight how metabolic diseases via cellular mechanisms affect muscle cells, skeletal muscle tissue, or human muscle morphology and function. Metabolic diseases are widely defined as metabolic insults that include not only obesity and diabetes, but also cancer, aging, stroke, COPD, and fasting, etc. Another goal is to identify therapeutic strategies (drug, exercise, nutrition etc) that promote skeletal muscle health and improve overall quality of life.
We welcome articles to this Research Topic from interested scientists, clinicians, and exercise specialists. Article types can include Original research, Reviews, Mini-Reviews, Short communications, and Perspectives articles related to metabolic diseases, but not limited to the following subtopics:
· Tissue morphology
· Fibrosis
· Insulin sensitivity
· Contractile function
· Energy efficiency
· Metabolism
· Mitochondria function
· Association with lipids
· Potential therapeutic strategies to target muscle
· Exercise therapy
Metabolic diseases such as obesity and diabetes cause disruption of systemic energy metabolism and is a major public health problem with at least 2 billion people worldwide. By contrast, skeletal muscle tissue makes a substantial contribution to promoting energy efficiency because it remodels cellular size, composition, and function in response to a variety of nutritional changes. However, metabolic diseases can dynamically affect the quantity and quality of skeletal muscle, including decreased contractile function, impaired insulin sensitivity, muscle atrophy, and cellular stress. A deeper understanding of myopathology in metabolic disorders could provide clues to therapeutic strategies.
The aim of this Research Topic is to highlight how metabolic diseases via cellular mechanisms affect muscle cells, skeletal muscle tissue, or human muscle morphology and function. Metabolic diseases are widely defined as metabolic insults that include not only obesity and diabetes, but also cancer, aging, stroke, COPD, and fasting, etc. Another goal is to identify therapeutic strategies (drug, exercise, nutrition etc) that promote skeletal muscle health and improve overall quality of life.
We welcome articles to this Research Topic from interested scientists, clinicians, and exercise specialists. Article types can include Original research, Reviews, Mini-Reviews, Short communications, and Perspectives articles related to metabolic diseases, but not limited to the following subtopics:
· Tissue morphology
· Fibrosis
· Insulin sensitivity
· Contractile function
· Energy efficiency
· Metabolism
· Mitochondria function
· Association with lipids
· Potential therapeutic strategies to target muscle
· Exercise therapy
