The name Triazole refers to a heterocycle with molecular formula C2H3N3, a five-membered ring of two carbon atoms and three nitrogen atoms. There are two sets of isomers (1,2,3-triazole and 1,2,4-triazole) that differ in the relative positions of the three nitrogen atoms. The triazole ring is an important isostere of oxazole, thiazole, imidazole, pyrazole, and so on. The aromaticity and electron richness of triazole enable it to readily bind with various types of enzymes and receptors via weak interactions such as hydrogen bonds, coordination bonds, ion-dipole, cation-p, hydrophobic effect, and van der Waals forces. Therefore, it has been widely employed in numerous fields, but especially in pharmaceutical research.
Many drugs (such as triazolam, alprazolam, Rufinamide, fluconazole, itraconazole, lamtidine, ribavirin, rassinazole, and sitagliptin) possessing a triazole moiety are already used in clinical treatment, and a huge number of triazole derivatives have been designed and prepared to investigate their pharmacological effects to develop new drugs. Recently, many 1,2,4-triazole derivatives have been reported in the field of anticonvulsant, anticancer, and antibacterial research. 1,2,3-triazoles in click chemistry have attracted research attention not only as a passive linker, but also an important pharmacophore through hydrogen-bonding and dipole interactions with biological targets.
This Research Topic intends to collect the latest contributions from researchers working on this versatile scaffold, looking for new synthetic strategies and new pharmacological applications of triazole derivatives. We welcome Original Research articles, Reviews, Mini reviews, and Perspectives. Areas to be covered in this collection may include, but are not limited to:
• New synthetic approaches for triazoles with biological activity
• Design and development of bioactive molecules containing triazole moiety
• Structure-activity-relationship studies on novel triazoles with pharmacological potential
• Triazole-based small molecules developed by rational drug design approach
• New pharmacological applications of triazole derivatives
The name Triazole refers to a heterocycle with molecular formula C2H3N3, a five-membered ring of two carbon atoms and three nitrogen atoms. There are two sets of isomers (1,2,3-triazole and 1,2,4-triazole) that differ in the relative positions of the three nitrogen atoms. The triazole ring is an important isostere of oxazole, thiazole, imidazole, pyrazole, and so on. The aromaticity and electron richness of triazole enable it to readily bind with various types of enzymes and receptors via weak interactions such as hydrogen bonds, coordination bonds, ion-dipole, cation-p, hydrophobic effect, and van der Waals forces. Therefore, it has been widely employed in numerous fields, but especially in pharmaceutical research.
Many drugs (such as triazolam, alprazolam, Rufinamide, fluconazole, itraconazole, lamtidine, ribavirin, rassinazole, and sitagliptin) possessing a triazole moiety are already used in clinical treatment, and a huge number of triazole derivatives have been designed and prepared to investigate their pharmacological effects to develop new drugs. Recently, many 1,2,4-triazole derivatives have been reported in the field of anticonvulsant, anticancer, and antibacterial research. 1,2,3-triazoles in click chemistry have attracted research attention not only as a passive linker, but also an important pharmacophore through hydrogen-bonding and dipole interactions with biological targets.
This Research Topic intends to collect the latest contributions from researchers working on this versatile scaffold, looking for new synthetic strategies and new pharmacological applications of triazole derivatives. We welcome Original Research articles, Reviews, Mini reviews, and Perspectives. Areas to be covered in this collection may include, but are not limited to:
• New synthetic approaches for triazoles with biological activity
• Design and development of bioactive molecules containing triazole moiety
• Structure-activity-relationship studies on novel triazoles with pharmacological potential
• Triazole-based small molecules developed by rational drug design approach
• New pharmacological applications of triazole derivatives
