About this Research Topic
The goal of this Research Topic is to identify immunomodulatory compounds purified from mushrooms and to explore their immune regulatory mechanisms, including their mechanisms of action and targets such as immune cells/molecules. Submissions on this topic will not only introduce new active compounds from mushrooms but also reveal novel immune regulatory mechanisms. Submitted manuscripts should adhere to the following requirements and scope:
1. The active compounds studied must be purified from mushrooms and subjected to explicit structural analysis. These compounds include, but are not limited to, polysaccharides, alkaloids, flavonoids, and various monomers.
2. The purified and structurally appraised compounds from mushrooms must demonstrate effects on immune regulation. Data obtained from in vitro experiments must be confirmed in animal models or preferably in clinical trials.
3. The study must clarify the mechanisms of action of the active compounds in the following areas, with clear delineation of their targets, such as cells and cytokines associated with immune functions:
(1) Autoregulation: the interaction of immune cells and immune molecules within the immune system;
(2) Global regulation: the interaction between the neuroendocrine and immune systems.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.