Mucosal and blood borne immune responses may provide complementary information crucial for accurate assessment of micro-organisms exposure after infection and immunization in both individuals and populations. IgA is the predominant immunoglobulin expressed at respiratory tract, cornea, and gastrointestinal tract mucosal surfaces, and IgA responses with neutralizing capability are described for several viral pathogens. Mucosal IgA exists predominantly as a dimer of two IgA monomers covalently linked together by J chain. Microorganisms enter cells mucosal by interacting with host proteins, and specific IgA antibodies are detected in various biological specimens, including serum, saliva, and breast milk. Neutralizing antibody titers are the best correlates of protection in most vaccines, and memory responses are responsible for protection from re-infection and are essential for effective vaccination.
This Research Topic aims to further characterize the IgA response to immunization with viruses and bacteria, the affinity and neutralization potency binding and neutralizing activity of serum and mucosal IgA produced by distinct lineages of memory B cells, and the consequences of IgA microbe binding. Longitudinal vaccine responses are critically important as well as the comparison of neutralizing activity by IgA generated by T cell-dependent and -independent pathways by immunization or natural infection at mucosal level. Moreover, this issue should give insight on IgA antibody longevity and vaccine induced memory B-cell generating IgA systemic and mucosal responses needed to protect from reinfection.
Specific themes of interest are:
o IgA affinity and neutralization potency binding
o neutralizing activity of serum and mucosal IgA produced by distinct lineages of memory B cells
o consequences of IgA microbe binding
o IgA- mediated longitudinal vaccine responses
o comparison of neutralizing activity by IgA generated by T cell-dependent and -independent pathways by immunization or natural infection at mucosal level
o IgA antibody longevity and vaccine induced memory B-cell generating IgA systemic and mucosal responses needed to protect from reinfection.
We welcome the following types of manuscripts:
o Original Research articles
o Reviews and Mini-Reviews
Mucosal and blood borne immune responses may provide complementary information crucial for accurate assessment of micro-organisms exposure after infection and immunization in both individuals and populations. IgA is the predominant immunoglobulin expressed at respiratory tract, cornea, and gastrointestinal tract mucosal surfaces, and IgA responses with neutralizing capability are described for several viral pathogens. Mucosal IgA exists predominantly as a dimer of two IgA monomers covalently linked together by J chain. Microorganisms enter cells mucosal by interacting with host proteins, and specific IgA antibodies are detected in various biological specimens, including serum, saliva, and breast milk. Neutralizing antibody titers are the best correlates of protection in most vaccines, and memory responses are responsible for protection from re-infection and are essential for effective vaccination.
This Research Topic aims to further characterize the IgA response to immunization with viruses and bacteria, the affinity and neutralization potency binding and neutralizing activity of serum and mucosal IgA produced by distinct lineages of memory B cells, and the consequences of IgA microbe binding. Longitudinal vaccine responses are critically important as well as the comparison of neutralizing activity by IgA generated by T cell-dependent and -independent pathways by immunization or natural infection at mucosal level. Moreover, this issue should give insight on IgA antibody longevity and vaccine induced memory B-cell generating IgA systemic and mucosal responses needed to protect from reinfection.
Specific themes of interest are:
o IgA affinity and neutralization potency binding
o neutralizing activity of serum and mucosal IgA produced by distinct lineages of memory B cells
o consequences of IgA microbe binding
o IgA- mediated longitudinal vaccine responses
o comparison of neutralizing activity by IgA generated by T cell-dependent and -independent pathways by immunization or natural infection at mucosal level
o IgA antibody longevity and vaccine induced memory B-cell generating IgA systemic and mucosal responses needed to protect from reinfection.
We welcome the following types of manuscripts:
o Original Research articles
o Reviews and Mini-Reviews
