Neurogenerative diseases are progressive disorders characterized by the dysfunction and loss of neurons and axons. Impairment of neuronal function results in cognitive deficits that affect millions of individuals worldwide. Whilst the triggers of these disorders vary, chronic inflammation is a common hallmark of neurogenerative diseases, which critically involves microglia activation. Inflammation, however, does not necessarily always lead to neurodegeneration and it can play a role in repair and regeneration. For example, clearing tissue debris following myelin damage is one the key function of activated microglia. Although the pathophysiology of neurodegeneration has been explored extensively, many open questions remain that require a deeper understanding of neuroinflammatory mechanisms.
The aim of this Research Topic is to explore the role of inflammation in the cellular and molecular pathologies that underlie neurodegenerative disorders. Ample data indicate the essential role of microglia in neuroinflammation, due to their ability to produce inflammatory cytokines. At the molecular level, the role of miRNAs in inflammation and oxidative stress has been evidenced by miRNA dysregulation that associates with neurodegenerative disorders and cancers due to mitochondrial DNA mutations. These pathologies demand further research that will compensate the limitations of currently available treatment strategies. The interplay between inflammation and neurodegeneration, and the protective role of inflammation is of particular interest. This Research Topic aims to provide new findings that will establish the background for developing promising treatments in future.
This Research Topic welcomes Original Research, Review Articles, Perspective and Opinion Articles on the following topics, but is not limited to:
• The role of microglia
• MiRNA regulation and dysregulation
• Pathological similarities between inflammation in neurodegenerative disorders and cancers
• The protective role of inflammation in neurodegeneration
We welcome in silico, in vitro and in vivo research, as well as clinically oriented studies. However, please note that the research using immortalized cell lines will be treated with caution.
Neurogenerative diseases are progressive disorders characterized by the dysfunction and loss of neurons and axons. Impairment of neuronal function results in cognitive deficits that affect millions of individuals worldwide. Whilst the triggers of these disorders vary, chronic inflammation is a common hallmark of neurogenerative diseases, which critically involves microglia activation. Inflammation, however, does not necessarily always lead to neurodegeneration and it can play a role in repair and regeneration. For example, clearing tissue debris following myelin damage is one the key function of activated microglia. Although the pathophysiology of neurodegeneration has been explored extensively, many open questions remain that require a deeper understanding of neuroinflammatory mechanisms.
The aim of this Research Topic is to explore the role of inflammation in the cellular and molecular pathologies that underlie neurodegenerative disorders. Ample data indicate the essential role of microglia in neuroinflammation, due to their ability to produce inflammatory cytokines. At the molecular level, the role of miRNAs in inflammation and oxidative stress has been evidenced by miRNA dysregulation that associates with neurodegenerative disorders and cancers due to mitochondrial DNA mutations. These pathologies demand further research that will compensate the limitations of currently available treatment strategies. The interplay between inflammation and neurodegeneration, and the protective role of inflammation is of particular interest. This Research Topic aims to provide new findings that will establish the background for developing promising treatments in future.
This Research Topic welcomes Original Research, Review Articles, Perspective and Opinion Articles on the following topics, but is not limited to:
• The role of microglia
• MiRNA regulation and dysregulation
• Pathological similarities between inflammation in neurodegenerative disorders and cancers
• The protective role of inflammation in neurodegeneration
We welcome in silico, in vitro and in vivo research, as well as clinically oriented studies. However, please note that the research using immortalized cell lines will be treated with caution.