Helicobacter pylori is one of the most common human pathogens which in the absence of appropriate therapy, colonizes the host's stomach throughout life. Despite the availability of many therapeutic management options, their effectiveness is declining from year to year and forces both scientists and clinicians around the world to revise the methods of eradication of this pathogen. In a widely accepted model, these problems are mainly caused by point mutations in the target sites of antibiotics. Fortunately, more attention is now being paid to the mechanisms promoting H. pylori tolerance to antimicrobial substances, which is the result of a series of physiological changes in bacterial cells and may lead to their insensitivity to several structurally different compounds at the same time.
The main purpose of this Research Topic is to therefore draw attention to the importance of tolerance and stress responses of H. pylori in the dissemination of antibiotic resistance and to deepen the knowledge of these still poorly characterized mechanisms of resistance and pathogenesis. Understanding these phenomena may contribute to the development of new types of therapies targeting H. pylori and the reduction of spreading of resistant and multidrug-resistant strains of this bacterium.
This Research Topic welcomes the submission of Original Research, Reviews, Mini Reviews and other article types accepted in the journal, focusing on the tolerance mechanisms promoting the survival of H. pylori under stressogenic conditions, especially antibiotic pressure. We welcome submissions on but not limited to:
• H. pylori participation of stringent response in defense reactions and survival mechanisms
• H. pylori biofilm formation
• H. pylori secretion of membrane vesicles
• H. pylori morphological transformation (coccoid forms and filamentous forms)
• Novel therapies targeting H. pylori virulence and survival mechanisms
Helicobacter pylori is one of the most common human pathogens which in the absence of appropriate therapy, colonizes the host's stomach throughout life. Despite the availability of many therapeutic management options, their effectiveness is declining from year to year and forces both scientists and clinicians around the world to revise the methods of eradication of this pathogen. In a widely accepted model, these problems are mainly caused by point mutations in the target sites of antibiotics. Fortunately, more attention is now being paid to the mechanisms promoting H. pylori tolerance to antimicrobial substances, which is the result of a series of physiological changes in bacterial cells and may lead to their insensitivity to several structurally different compounds at the same time.
The main purpose of this Research Topic is to therefore draw attention to the importance of tolerance and stress responses of H. pylori in the dissemination of antibiotic resistance and to deepen the knowledge of these still poorly characterized mechanisms of resistance and pathogenesis. Understanding these phenomena may contribute to the development of new types of therapies targeting H. pylori and the reduction of spreading of resistant and multidrug-resistant strains of this bacterium.
This Research Topic welcomes the submission of Original Research, Reviews, Mini Reviews and other article types accepted in the journal, focusing on the tolerance mechanisms promoting the survival of H. pylori under stressogenic conditions, especially antibiotic pressure. We welcome submissions on but not limited to:
• H. pylori participation of stringent response in defense reactions and survival mechanisms
• H. pylori biofilm formation
• H. pylori secretion of membrane vesicles
• H. pylori morphological transformation (coccoid forms and filamentous forms)
• Novel therapies targeting H. pylori virulence and survival mechanisms