Heart failure (HF) is a growing public health issue worldwide. Despite the progress that has been made in the treatment of HF, there is still a high annual mortality. Approximately 6.2 million adults in the United States have been diagnosed with HF, with a five-year survival rate of about 50% for all stages. The causes of HF including cardiomyopathy, hypertension, aging, myocardial infarction, remain unknown. Myocardial infarction is the major cause of heart failure due to myocardial necrosis, myocardial stunning and subsequent cardiac remodeling. Currently, heart failure has no cure. Thus the study of new mechanisms to seek novel therapeutic targets or approaches to improve the clinical course of HF patients is urgently needed. With the discovery of novel molecular mechanisms and drug targets, targeting cardiac remodeling using pharmacological small molecules or stem cell based-approaches may provide new possible therapeutic strategies in HF. Importantly, the identification of novel molecular biomarkers is also helpful for the management and development of precise therapies for HF patients.
This Research topic aims to provide novel insights into the major advances made in the understanding of mechanisms, drug targets and cardiac repair for treating heart failure in translational medicine. This research topic welcomes Original Research, Reviews, Mini Reviews, Systematic Reviews and General Commentaries.
Areas to be covered in this Research Topic may include, but are not limited to：
· Mechanistic understanding of cardiac remodeling during the progression of heart failure
· Novel pharmacological approaches for cardiac remodeling
· Stem cell based-approaches for cardiac repair
· Molecular biomarkers for cardiac remodeling
Heart failure (HF) is a growing public health issue worldwide. Despite the progress that has been made in the treatment of HF, there is still a high annual mortality. Approximately 6.2 million adults in the United States have been diagnosed with HF, with a five-year survival rate of about 50% for all stages. The causes of HF including cardiomyopathy, hypertension, aging, myocardial infarction, remain unknown. Myocardial infarction is the major cause of heart failure due to myocardial necrosis, myocardial stunning and subsequent cardiac remodeling. Currently, heart failure has no cure. Thus the study of new mechanisms to seek novel therapeutic targets or approaches to improve the clinical course of HF patients is urgently needed. With the discovery of novel molecular mechanisms and drug targets, targeting cardiac remodeling using pharmacological small molecules or stem cell based-approaches may provide new possible therapeutic strategies in HF. Importantly, the identification of novel molecular biomarkers is also helpful for the management and development of precise therapies for HF patients.
This Research topic aims to provide novel insights into the major advances made in the understanding of mechanisms, drug targets and cardiac repair for treating heart failure in translational medicine. This research topic welcomes Original Research, Reviews, Mini Reviews, Systematic Reviews and General Commentaries.
Areas to be covered in this Research Topic may include, but are not limited to：
· Mechanistic understanding of cardiac remodeling during the progression of heart failure
· Novel pharmacological approaches for cardiac remodeling
· Stem cell based-approaches for cardiac repair
· Molecular biomarkers for cardiac remodeling