The musculoskeletal system, providing the structure and function of the human body, is composed mainly of connective tissues such as bone, muscle, joints, intervertebral discs, tendons, and ligaments. The environmental biomechanical and biochemical factors, at the tissue, cellular or molecular levels, are of fundamental importance in the regulation of the musculoskeletal system. The mechanisms of how these external clues are sensed, cascaded, and translated into intracellular signaling response, however, are not fully elucidated. Understanding the underlying mechanisms will shed light on the regulation of musculoskeletal tissue, which could greatly facilitate the new therapeutic strategies and drug development for musculoskeletal disorders.
The underlying mechanisms of how environmental clues, either biomechanical or biochemical are translated into cellular signaling and subsequent response are still poorly understood, which is the key to understanding the pathology of musculoskeletal tissue for new clinical strategies. Recent advances have shed light on potential mechanisms of musculoskeletal cells directly or indirectly sensing extracellular mechanical stimuli and circulating hormones or cytokines, and ultimately altering the intracellular response. These achievements from both in vitro cell studies and in vivo animal studies, have brought us closer to understanding the physiology of musculoskeletal tissue in health and disease. Under this context, this intended collection of articles will explore topics in biomechanical and biochemical regulation of the musculoskeletal system.
This Research Topic aims to highlight the recent progress on biomechanical regulation of the musculoskeletal system. This Topic is committed to the publication of Original Research, Reviews, and Perspective articles on, but not limited to, the following themes:
• Cellular signaling pathways regulating the mechanotransduction in musculoskeletal pathological diseases or disorders
• The mechanism of circulating hormones or extracellular cytokines regulating musculoskeletal cell
• The approach of fluid mechanics to investigate the musculoskeletal cell mechanobiology
• The role of solute transport on the repair of musculoskeletal tissues
• The role and implications of extracellular mechanical stimulated calcium signaling in musculoskeletal cells
• The impact of female sex hormones on the maternal musculoskeletal health during the reproduction cycles
• Finite element approach for the biomechanics of musculoskeletal tissue
We would like to acknowledge Dr. Yilu Zhou as the Topic Co-ordinator for this Research Topic, and thank him for his efforts in developing the Topic.
The musculoskeletal system, providing the structure and function of the human body, is composed mainly of connective tissues such as bone, muscle, joints, intervertebral discs, tendons, and ligaments. The environmental biomechanical and biochemical factors, at the tissue, cellular or molecular levels, are of fundamental importance in the regulation of the musculoskeletal system. The mechanisms of how these external clues are sensed, cascaded, and translated into intracellular signaling response, however, are not fully elucidated. Understanding the underlying mechanisms will shed light on the regulation of musculoskeletal tissue, which could greatly facilitate the new therapeutic strategies and drug development for musculoskeletal disorders.
The underlying mechanisms of how environmental clues, either biomechanical or biochemical are translated into cellular signaling and subsequent response are still poorly understood, which is the key to understanding the pathology of musculoskeletal tissue for new clinical strategies. Recent advances have shed light on potential mechanisms of musculoskeletal cells directly or indirectly sensing extracellular mechanical stimuli and circulating hormones or cytokines, and ultimately altering the intracellular response. These achievements from both in vitro cell studies and in vivo animal studies, have brought us closer to understanding the physiology of musculoskeletal tissue in health and disease. Under this context, this intended collection of articles will explore topics in biomechanical and biochemical regulation of the musculoskeletal system.
This Research Topic aims to highlight the recent progress on biomechanical regulation of the musculoskeletal system. This Topic is committed to the publication of Original Research, Reviews, and Perspective articles on, but not limited to, the following themes:
• Cellular signaling pathways regulating the mechanotransduction in musculoskeletal pathological diseases or disorders
• The mechanism of circulating hormones or extracellular cytokines regulating musculoskeletal cell
• The approach of fluid mechanics to investigate the musculoskeletal cell mechanobiology
• The role of solute transport on the repair of musculoskeletal tissues
• The role and implications of extracellular mechanical stimulated calcium signaling in musculoskeletal cells
• The impact of female sex hormones on the maternal musculoskeletal health during the reproduction cycles
• Finite element approach for the biomechanics of musculoskeletal tissue
We would like to acknowledge Dr. Yilu Zhou as the Topic Co-ordinator for this Research Topic, and thank him for his efforts in developing the Topic.
