Bacteriophages, also known as phages, are the most abundant organisms on earth. Although they have lived in our world for billions of years, phages have been discovered only for a century. Nevertheless, studies on phages have revolutionized the basic and applied fields of biological sciences, medicines, and material sciences. In 1985, George P. Smith invented the phage display technique for screening random peptide library displayed on phage. Later, Sir Gregory P. Winter extended this technique for antibody screening. In 2018, one half of the Nobel Prize in Chemistry was awarded jointly to them "for the phage display of peptides and antibodies". Phage display has been widely used to map epitopes, identify drug targets, and develop therapeutics, diagnostics, and vaccines.
This research topic will include the recent advances of phage display technique and its applications such as phage vector and library construction, phage display powered by next-generation sequencing, epitope mapping, drug target identification, development of therapeutics, diagnostics, and vaccines. In addition to wet lab studies, it will also address the frontiers of dry lab studies in the field of phage display, from benchmarks, databases, mathematics models, machine learning methods to web servers. Thus, we hope a cocktail research topic of wet and dry lab studies on phage display and its application will benefit all relevant fields.
This Research Topic will accept Original Research, Opinions, Perspectives and Reviews on phage display techniques and their applications in all kinds of fields. The topic mainly includes but is not limited to: phage vector and library, antibody phage display, peptide phage display, drug target identification, epitope mapping, the discovery of lead peptide or antibody for therapeutics, diagnostics, and vaccines development, and relevant benchmarks, databases, mathematics models, machine learning methods, and web tools.
Bacteriophages, also known as phages, are the most abundant organisms on earth. Although they have lived in our world for billions of years, phages have been discovered only for a century. Nevertheless, studies on phages have revolutionized the basic and applied fields of biological sciences, medicines, and material sciences. In 1985, George P. Smith invented the phage display technique for screening random peptide library displayed on phage. Later, Sir Gregory P. Winter extended this technique for antibody screening. In 2018, one half of the Nobel Prize in Chemistry was awarded jointly to them "for the phage display of peptides and antibodies". Phage display has been widely used to map epitopes, identify drug targets, and develop therapeutics, diagnostics, and vaccines.
This research topic will include the recent advances of phage display technique and its applications such as phage vector and library construction, phage display powered by next-generation sequencing, epitope mapping, drug target identification, development of therapeutics, diagnostics, and vaccines. In addition to wet lab studies, it will also address the frontiers of dry lab studies in the field of phage display, from benchmarks, databases, mathematics models, machine learning methods to web servers. Thus, we hope a cocktail research topic of wet and dry lab studies on phage display and its application will benefit all relevant fields.
This Research Topic will accept Original Research, Opinions, Perspectives and Reviews on phage display techniques and their applications in all kinds of fields. The topic mainly includes but is not limited to: phage vector and library, antibody phage display, peptide phage display, drug target identification, epitope mapping, the discovery of lead peptide or antibody for therapeutics, diagnostics, and vaccines development, and relevant benchmarks, databases, mathematics models, machine learning methods, and web tools.
