115.4K
views
197
authors
28
articles
Editors
4
Impact
Loading...

Objectives: To determine the therapeutic effect of a Mediterranean diet (MED) combined with a low-carbohydrate (LC) dietary model in overweight polycystic ovary syndrome (PCOS) patients.

Methods: In this 12-week randomized controlled clinical trial, 72 overweight patients with PCOS were randomly assigned to one of two energy-restricted dietary models: the MED/LC diet or the Low fat (LF) diet. After the intervention, the number of the two groups returned to normal menstruation was counted. Body weight, body mass index (BMI), waist circumference, waist-hip ratio (WHR), body fat percentage (BF%), serum fasting insulin(FINS), fasting plasma glucose(FPG), insulin resistance index (HOMA-IR), quantitative insulin sensitivity index (QUIKI), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) were compared between 2 groups before and after intervention.

Results: MED/LC group had more significant reduction trend in weight (−6.10 ± 1.52 kg vs −4.79 ± 0.97 kg, P < 0.05), BMI (−2.12 ± 0.57 kg/m2 vs −1.78 ± 0.36 kg/m2, P < 0.05), WC (−6.12 ± 5.95 cm vs −3.90 ± 1.58 cm, P < 0.05), WHR (−0.06 ± 0.02 vs −0.03 ± 0.02, P < 0.05), BF% (−2.97% ± 1.78% vs −1.19% ± 0.91%, P < 0.05), TT (−0.20 ± 0.24 ng/mL vs 0.08 ± 0.11 ng/Ml, P < 0.001), LH (−5.28 ± 3.31 mIU/mL vs −3.39 ± 3.64 mIU/mL, P < 0.05), and LH/FSH (−1.18 ± 0.75 vs -0.66 ± 1.05, P < 0.05) compared with the LF group. In addition, FPG (0.05 ± 0.38 mmol/mL vs -0.50 ± 1.01 mmol/mL, P < 0.001), FINS (−4.88 ± 6.11 μU/mL vs −8.53 ± 5.61 μU/mL, P < 0.01), HOMA-IR index (−1.11 ± 1.51 vs −2.23 ± 0.25, P < 0.05), and QUIKI index (0.014 ± 0.016 vs 0.028 ± 0.019, P < 0.05) decreased significantly in the MED/LC group compared with the LF group. Comparing the changes in lipid parameters between the two groups (LF vs MED/LC), significant differences in TG (−0.33 ± 0.32 mmol vs −0.76 ± 0.97 mmol, P < 0.05), TC (−0.40 ± 1.00 mmol vs −1.45 ± 2.00 mmol, P < 0.05), and LDL-C (−0.41 ± 1.05 mmol vs −0.73 ± 0.76 mmol, P < 0.05) were observed.

Conclusion: The results of this study suggest that the MED/LC diet model is a good treatment for overweight PCOS patients, significantly restoring their menstrual cycle, improving their anthropometric parameters and correcting their disturbed endocrine levels, and its overall effectiveness is significantly better than the LF diet model. Therefore, this study recommends that the MED/LC diet model can be used in the clinical treatment of patients with overweight PCOS.

17,482 views
31 citations
Fetching...
Recommended Research Topics
Frontiers Logo

Frontiers in Nutrition

The Chemistry of Food in the Advent of Sustainable Diets
Edited by Márcio Carocho, Lillian Barros, Patricia Morales, Spyridon Alexandros Petropoulos, Marina Sokovic
39.5K
views
8
articles
Frontiers Logo

Frontiers in Nutrition

Food Melanoidins: Chemistry and Nutrition
Edited by Fernando M. Nunes, Dolores Del Castillo, Franck Carbonero
40K
views
6
articles
Frontiers Logo

Frontiers in Nutrition

Global Excellence in Food Chemistry
Edited by A. M. Abd El-Aty, Jesus Simal-Gandara, Alaa El-Din Ahmed Bekhit
125.5K
views
148
authors
21
articles
Frontiers Logo

Frontiers in Nutrition

Women in Food Chemistry
Edited by Yasmina Sultanbawa, Dharini Sivakumar, Michele Iskandar
13.2K
views
34
authors
5
articles
Frontiers Logo

Frontiers in Nutrition

Rising Stars in Food Chemistry: Insights on Plant Polyphenols and Their Polymers
Edited by Hongkai Zhu, Liang Zeng, Paul Kilmartin, Qunfeng Zhang, Youben Yu
24.5K
views
59
authors
8
articles