Proteases are considered to be a large and complex group of enzymes of the hydrolyses class. Proteases cleave the peptide bonds of peptides and proteins. Approximately 2% of the genome of living organisms encodes proteases, which are involved in different vital physiological processes in cells. Different enzymes, specifically microbial proteases, are the most essentially used in different corporate sectors, such as textile, detergent, leather, feed, waste, and others. Proteases with respect to physiological and commercial roles hold a pivotal position. As they are performing synthetic and degradative functions, are found ubiquitously, such as in plants, animals, and microbes. Among different producers of proteases, Bacillus sp. are mostly commercially exploited microbes for proteases. Proteases are successfully considered as an alternative to chemicals and an eco-friendly indicator for nature or the surroundings. The evolutionary relationship among acidic, neutral, and alkaline proteases has been analyzed based on their protein sequences, but there remains a lack of information that regulates the diversity in their specificity. Researchers are looking for microbial proteases as they can tolerate harsh conditions, ways to prevent autoproteolytic activity, stability in optimum pH, and substrate specificity. Using immobilization processes, we can add to proteases, improved properties, such as their reuse, a profound change on their physico-chemical properties, such as pH, activity and in protein-protein, protein-subtract, interactions, etc. Thus, different immobilization methods can be applied, such as reversible, covalent immobilization, by hydrophobicity, by affinity etc. All this will make its use on an industrial scale highly improved.
Proteases are present in all organisms, knowledge about these macromolecules at the biochemical and physiological level helps to understand their application in various industrial sectors, and also to understand pathological processes involving proteases, in the search for inhibitors, for example.
Techniques such as determining the specificity of proteases are being used to understand the mode of action of these enzymes in physiological processes of microorganisms, and thus discover ways to inhibit these proteases in pathological processes and application in industrial sectors.
Proteases from microorganisms have plasticity characteristics in terms of specificity and biochemical parameters, making them special in industrial applications.
This research topic on microbial proteases aims to gather information about the action of proteases both in the field of biochemistry and microbial physiology and their applications in various industrial sectors.
Especially welcome are contribution focusing on but not limited to:
- Proteases in biotechnological processes
- Proteases in Pathological Processes in Humans and Plants (with the exclusion of biomedical focused manuscripts)
- Protease immobilization and application
- Microbial Proteases: Structural and Biochemical characterization
- Microbial Proteases applied in different industrial sectors
Proteases are considered to be a large and complex group of enzymes of the hydrolyses class. Proteases cleave the peptide bonds of peptides and proteins. Approximately 2% of the genome of living organisms encodes proteases, which are involved in different vital physiological processes in cells. Different enzymes, specifically microbial proteases, are the most essentially used in different corporate sectors, such as textile, detergent, leather, feed, waste, and others. Proteases with respect to physiological and commercial roles hold a pivotal position. As they are performing synthetic and degradative functions, are found ubiquitously, such as in plants, animals, and microbes. Among different producers of proteases, Bacillus sp. are mostly commercially exploited microbes for proteases. Proteases are successfully considered as an alternative to chemicals and an eco-friendly indicator for nature or the surroundings. The evolutionary relationship among acidic, neutral, and alkaline proteases has been analyzed based on their protein sequences, but there remains a lack of information that regulates the diversity in their specificity. Researchers are looking for microbial proteases as they can tolerate harsh conditions, ways to prevent autoproteolytic activity, stability in optimum pH, and substrate specificity. Using immobilization processes, we can add to proteases, improved properties, such as their reuse, a profound change on their physico-chemical properties, such as pH, activity and in protein-protein, protein-subtract, interactions, etc. Thus, different immobilization methods can be applied, such as reversible, covalent immobilization, by hydrophobicity, by affinity etc. All this will make its use on an industrial scale highly improved.
Proteases are present in all organisms, knowledge about these macromolecules at the biochemical and physiological level helps to understand their application in various industrial sectors, and also to understand pathological processes involving proteases, in the search for inhibitors, for example.
Techniques such as determining the specificity of proteases are being used to understand the mode of action of these enzymes in physiological processes of microorganisms, and thus discover ways to inhibit these proteases in pathological processes and application in industrial sectors.
Proteases from microorganisms have plasticity characteristics in terms of specificity and biochemical parameters, making them special in industrial applications.
This research topic on microbial proteases aims to gather information about the action of proteases both in the field of biochemistry and microbial physiology and their applications in various industrial sectors.
Especially welcome are contribution focusing on but not limited to:
- Proteases in biotechnological processes
- Proteases in Pathological Processes in Humans and Plants (with the exclusion of biomedical focused manuscripts)
- Protease immobilization and application
- Microbial Proteases: Structural and Biochemical characterization
- Microbial Proteases applied in different industrial sectors
