Antibiotic resistance is exuberantly becoming a deleterious health problem worldwide. Seeking innovative approaches is necessary in order to circumvent such a hazard. An unconventional fill-in to antibiotics is bacteriophage. Bacteriophages are viruses capable of pervading bacterial cells and disrupting their natural activity, ultimately resulting in their defeat.
Being on the cusp of post-antibiotic era, phages could be our allies, and enactment of phage therapy might be a fortunate trailblazer in the global fight against bacterial resistance. Certainly, several question marks still hover around bacteriophages, such as their ability for horizontal gene transfer, the interaction dynamics with the human microbiome, and the different findings on their immunomodulatory effects; all of these need to be tackled prior to their application for therapy. Hence, the integration of phage therapy, their lytic proteins, and engineered phages, while keeping the efforts addressing the antibiotics’ problems is of utmost importance facing such a huge issue. This is an attempt to encourage tackling a long-forgotten hive. Perhaps, one day, the smallest of the creatures would be of the greatest help.
This Research Topic seeks manuscripts that discuss:
- the potential of bacteriophage as a therapeutic antibacterial agent
- phage-antibiotic combinations and their use in therapy
- other phage applications
- limitations of phage therapy and obstacles towards real-life application
- characterization and production optimization
- phage pharmacokinetics and pharmacodynamics
- phage formulation challenges and potential solutions
- phage proteins and enzymes applications
We welcome Original Research, Reviews, Brief Research Reports, and Mini Reviews.
Antibiotic resistance is exuberantly becoming a deleterious health problem worldwide. Seeking innovative approaches is necessary in order to circumvent such a hazard. An unconventional fill-in to antibiotics is bacteriophage. Bacteriophages are viruses capable of pervading bacterial cells and disrupting their natural activity, ultimately resulting in their defeat.
Being on the cusp of post-antibiotic era, phages could be our allies, and enactment of phage therapy might be a fortunate trailblazer in the global fight against bacterial resistance. Certainly, several question marks still hover around bacteriophages, such as their ability for horizontal gene transfer, the interaction dynamics with the human microbiome, and the different findings on their immunomodulatory effects; all of these need to be tackled prior to their application for therapy. Hence, the integration of phage therapy, their lytic proteins, and engineered phages, while keeping the efforts addressing the antibiotics’ problems is of utmost importance facing such a huge issue. This is an attempt to encourage tackling a long-forgotten hive. Perhaps, one day, the smallest of the creatures would be of the greatest help.
This Research Topic seeks manuscripts that discuss:
- the potential of bacteriophage as a therapeutic antibacterial agent
- phage-antibiotic combinations and their use in therapy
- other phage applications
- limitations of phage therapy and obstacles towards real-life application
- characterization and production optimization
- phage pharmacokinetics and pharmacodynamics
- phage formulation challenges and potential solutions
- phage proteins and enzymes applications
We welcome Original Research, Reviews, Brief Research Reports, and Mini Reviews.