Neurological disorders are a group of diseases that affect the structure or function of the central and peripheral nervous system. There are more than 600 neurologic diseases. Some representative central nervous system diseases include neurodevelopmental diseases caused by defective genes or hazardous environmental factors or Gene × Environment interactions, such as Autism Spectrum Disorders (ASDs); diseases of the blood vessels that supply the brain, such as stroke; neurodegenerative diseases where nerve cells are damaged or die, such as Parkinson's disease (PD) and Alzheimer's disease (AD); as well as major depressive and bipolar disorders which present with psychiatric symptoms.
Hundreds of millions of people worldwide are affected by central nervous system disorders. For example, ASDs affect around 1-2% of the world population and more than 6 million people die because of stroke each year. It is estimated that 9.4 million people live with PD and 44 million people live with AD or a related form of dementia. An estimated 3.8% of the world’s population (approximately 280 million people) are suffering from depression, and the COVID-19 pandemic has tripled the prevalence of depression symptoms in U.S. adults. Although these neurological disorders place a significant burden on society and individuals, the pathogenesis of these diseases is not yet fully understood. This greatly restricts the development of new drugs and novel therapeutic strategies.
This Research Topic aims to bring together the most recent and advanced work on novel technologies identifying disease biomarkers, such as morphological and functional imaging technologies. Novel animal models of neurological disorders, including ASDs, stroke, PD, AD and depression, are also welcomed. This will help to advance our understanding of pathogenesis and explore novel therapeutic strategies. We would specifically encourage studies in, but are not limited to, the following topics:
• Original research that proposes novel technologies to identify biomarkers, which can be utilized to predict disease states, prognosis and responses to therapy.
• Original research that establishes novel animal models (such as non-human primate models), or uses existing animal models to unravel new mechanisms and/or novel therapeutic strategies.
• Methods or Reviews on current developments in biomarker detection technologies and/or animal models, including improvements to existing technologies, models, paradigms and/or therapies.
• Systematic or meta-analytic reviews that address face, construct and predictive validity of animal models.
Neurological disorders are a group of diseases that affect the structure or function of the central and peripheral nervous system. There are more than 600 neurologic diseases. Some representative central nervous system diseases include neurodevelopmental diseases caused by defective genes or hazardous environmental factors or Gene × Environment interactions, such as Autism Spectrum Disorders (ASDs); diseases of the blood vessels that supply the brain, such as stroke; neurodegenerative diseases where nerve cells are damaged or die, such as Parkinson's disease (PD) and Alzheimer's disease (AD); as well as major depressive and bipolar disorders which present with psychiatric symptoms.
Hundreds of millions of people worldwide are affected by central nervous system disorders. For example, ASDs affect around 1-2% of the world population and more than 6 million people die because of stroke each year. It is estimated that 9.4 million people live with PD and 44 million people live with AD or a related form of dementia. An estimated 3.8% of the world’s population (approximately 280 million people) are suffering from depression, and the COVID-19 pandemic has tripled the prevalence of depression symptoms in U.S. adults. Although these neurological disorders place a significant burden on society and individuals, the pathogenesis of these diseases is not yet fully understood. This greatly restricts the development of new drugs and novel therapeutic strategies.
This Research Topic aims to bring together the most recent and advanced work on novel technologies identifying disease biomarkers, such as morphological and functional imaging technologies. Novel animal models of neurological disorders, including ASDs, stroke, PD, AD and depression, are also welcomed. This will help to advance our understanding of pathogenesis and explore novel therapeutic strategies. We would specifically encourage studies in, but are not limited to, the following topics:
• Original research that proposes novel technologies to identify biomarkers, which can be utilized to predict disease states, prognosis and responses to therapy.
• Original research that establishes novel animal models (such as non-human primate models), or uses existing animal models to unravel new mechanisms and/or novel therapeutic strategies.
• Methods or Reviews on current developments in biomarker detection technologies and/or animal models, including improvements to existing technologies, models, paradigms and/or therapies.
• Systematic or meta-analytic reviews that address face, construct and predictive validity of animal models.