In the past decade, the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD) has increasingly been examined, and a concept termed "cardiorenal syndrome" has been advocated. When the failure of one of the systems negatively affects another, the crosstalk between the cardiovascular system and the kidney becomes obvious. Some features are common in both heart failure and chronic kidney disease, such as oxidative stress, inflammation, fibrosis, mitochondrial autophagy, and metabolism leading to organ remodeling. However, the pathophysiology of the syndrome involves complex, multifactorial, and dynamic mechanisms, and remains unclear.
At present, new imaging technology and biomarkers are used to diagnose the cardiorenal syndrome. Focusing on special populations such as diabetes and kidney transplant patients, there have been evolved many new clinical views towards cardiorenal syndrome. Current treatments mainly include the correction of volume overload and neuroendocrine regulation, such as Sacubitril valsartan, glucagon-likepeptide-1 and beta-receptor blockers etc. But the prognosis of patients with cardiorenal syndrome is still not well improved. To achieve prognosis improvement, further investigation is needed to predict and early identify the cardiorenal syndrome, control risk factors and discover new therapeutic targets.
The goal of this Research Topic is to identify mediators potentially contributing to the crosstalk between the kidney and the cardiovascular system for allowing development of predictive model and identification of novel therapeutic targets addressing both systems.
We welcome Original Research, Review, and Mini-review in the following subtopics, but not limited to:
1) The pathogenesis of cardiorenal syndromes.
2) Imaging in Cardiorenal Syndromes.
3) Mitochondrial autophagy in cardiovascular and renal disease.
4) Oxidative stress in cardiovascular and renal disease.
5) Nutrition and metabolism in cardiovascular and renal disease.
6) Biomarkers & therapeutic for cardiovascular and renal disease.
7) Development of predictive models for cardiovascular and renal disease.
8) Epidemiology of cardiovascular and renal disease.
In the past decade, the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD) has increasingly been examined, and a concept termed "cardiorenal syndrome" has been advocated. When the failure of one of the systems negatively affects another, the crosstalk between the cardiovascular system and the kidney becomes obvious. Some features are common in both heart failure and chronic kidney disease, such as oxidative stress, inflammation, fibrosis, mitochondrial autophagy, and metabolism leading to organ remodeling. However, the pathophysiology of the syndrome involves complex, multifactorial, and dynamic mechanisms, and remains unclear.
At present, new imaging technology and biomarkers are used to diagnose the cardiorenal syndrome. Focusing on special populations such as diabetes and kidney transplant patients, there have been evolved many new clinical views towards cardiorenal syndrome. Current treatments mainly include the correction of volume overload and neuroendocrine regulation, such as Sacubitril valsartan, glucagon-likepeptide-1 and beta-receptor blockers etc. But the prognosis of patients with cardiorenal syndrome is still not well improved. To achieve prognosis improvement, further investigation is needed to predict and early identify the cardiorenal syndrome, control risk factors and discover new therapeutic targets.
The goal of this Research Topic is to identify mediators potentially contributing to the crosstalk between the kidney and the cardiovascular system for allowing development of predictive model and identification of novel therapeutic targets addressing both systems.
We welcome Original Research, Review, and Mini-review in the following subtopics, but not limited to:
1) The pathogenesis of cardiorenal syndromes.
2) Imaging in Cardiorenal Syndromes.
3) Mitochondrial autophagy in cardiovascular and renal disease.
4) Oxidative stress in cardiovascular and renal disease.
5) Nutrition and metabolism in cardiovascular and renal disease.
6) Biomarkers & therapeutic for cardiovascular and renal disease.
7) Development of predictive models for cardiovascular and renal disease.
8) Epidemiology of cardiovascular and renal disease.
