A large amount of convincing evidence has accumulated to show that the medical conditions associated with chronic inflammation and immunological abnormalities are frequently observed in multiple classic neurological and psychiatric disorders, such as Parkinson, Alzheimer's disease, autism spectrum disorder, schizophrenia, multiple sclerosis, neuropsychiatric lupus erythematosus and so on. Interestingly, some of these neurological and psychiatric disorders have been considered as potential autoimmune diseases. During the last few years, many attempts have been made towards the understanding of the immunological mechanisms involving in neuroendocrine function, synaptic plasticity, and neurocircuits. However, much less is known about the mechanisms linking immune system to neurological and psychiatric disorders.
Determining how the immune system and neuro-psychiatric disorders interact with each other could significantly improve our understanding of psychosis and give rise to effective treatment options. Therefore, studies that address possible immunological mechanisms and the use of a biomarker in association with response to a treatment are very important. These studies can guide the clinicians to identify subpopulations or somatic comorbidities and improve diagnosis and targeted treatment for patients.
The goal of this research topic is to stimulate both basic and translational research that may optimize clinical practice in the cross field of classic autoimmune diseases and neurological/psychiatric disorders. We welcome submissions that focus on new insights of the mechanisms of immune dysregulation and autoimmunity/autoinflammation in neuro-psychiatric disorders, including the roles of immune cells such as T cells and microglia, and immune molecules such as cytokines and chemokines in the pathogenesis of these diseases. In addition, biomarkers for diagnosis and therapeutic response are also of interest, as well as the role of immunomodulators in the management of some of these conditions.
We strongly encourage original research submissions but reviews, perspectives, case reports and hypothesis and theory articles are also welcomed. The Research Topic will accept manuscripts from, but not limited to the following subtopics:
1. Genetic and epidemiological research on investigating immune biomarkers for neurological and psychiatric disorders.
2. Autoimmunity/autoinflammation mechanisms of underlying developmental processes in individual with neurological and psychiatric disorders.
3. Shared or unique mechanisms between classic autoimmune diseases and potential autoimmune diseases such as neuro-psychiatric disorders.
4. The role of regulatory T cells and Th17 cells in the development of neurological and psychiatric disorders.
5. The role of microglia cells in the development of neurological and psychiatric disorders.
6. Structural neuroimaging and functional brain connectivity difference in the individuals with autoimmune diseases and neurological and psychiatric disorders.
7. Shared and unique properties inherent to autoimmune diseases and neuro-psychiatric disorders, predicting the long-term outcome and related risk factors.
8. Potential therapeutical molecules for relief or treatment of classic autoimmune diseases and potential autoimmune diseases such as neuro-psychiatric disorders.
A large amount of convincing evidence has accumulated to show that the medical conditions associated with chronic inflammation and immunological abnormalities are frequently observed in multiple classic neurological and psychiatric disorders, such as Parkinson, Alzheimer's disease, autism spectrum disorder, schizophrenia, multiple sclerosis, neuropsychiatric lupus erythematosus and so on. Interestingly, some of these neurological and psychiatric disorders have been considered as potential autoimmune diseases. During the last few years, many attempts have been made towards the understanding of the immunological mechanisms involving in neuroendocrine function, synaptic plasticity, and neurocircuits. However, much less is known about the mechanisms linking immune system to neurological and psychiatric disorders.
Determining how the immune system and neuro-psychiatric disorders interact with each other could significantly improve our understanding of psychosis and give rise to effective treatment options. Therefore, studies that address possible immunological mechanisms and the use of a biomarker in association with response to a treatment are very important. These studies can guide the clinicians to identify subpopulations or somatic comorbidities and improve diagnosis and targeted treatment for patients.
The goal of this research topic is to stimulate both basic and translational research that may optimize clinical practice in the cross field of classic autoimmune diseases and neurological/psychiatric disorders. We welcome submissions that focus on new insights of the mechanisms of immune dysregulation and autoimmunity/autoinflammation in neuro-psychiatric disorders, including the roles of immune cells such as T cells and microglia, and immune molecules such as cytokines and chemokines in the pathogenesis of these diseases. In addition, biomarkers for diagnosis and therapeutic response are also of interest, as well as the role of immunomodulators in the management of some of these conditions.
We strongly encourage original research submissions but reviews, perspectives, case reports and hypothesis and theory articles are also welcomed. The Research Topic will accept manuscripts from, but not limited to the following subtopics:
1. Genetic and epidemiological research on investigating immune biomarkers for neurological and psychiatric disorders.
2. Autoimmunity/autoinflammation mechanisms of underlying developmental processes in individual with neurological and psychiatric disorders.
3. Shared or unique mechanisms between classic autoimmune diseases and potential autoimmune diseases such as neuro-psychiatric disorders.
4. The role of regulatory T cells and Th17 cells in the development of neurological and psychiatric disorders.
5. The role of microglia cells in the development of neurological and psychiatric disorders.
6. Structural neuroimaging and functional brain connectivity difference in the individuals with autoimmune diseases and neurological and psychiatric disorders.
7. Shared and unique properties inherent to autoimmune diseases and neuro-psychiatric disorders, predicting the long-term outcome and related risk factors.
8. Potential therapeutical molecules for relief or treatment of classic autoimmune diseases and potential autoimmune diseases such as neuro-psychiatric disorders.
