Abnormal metabolites and hormones play an important role in the pathogenesis of metabolic diseases such as type 2 diabetes, nonalcoholic fatty liver disease and polycystic ovary syndrome. Gut microbiota and its related metabolites such as bile acids, amino acids and lipids regulate the occurrence and development of metabolic diseases by directly acting on target organs or affecting the immune system and hormone homeostasis. There is a complex interaction between hormones (insulin, growth hormone, and sex hormone) and metabolites such as glucose, lipid and amino acid. The regulatory effect of bile acid and other metabolites and hormone abnormalities on metabolic diseases is still unclear. An in-depth investigation of the homeostasis regulation of metabolites and hormones and their interaction on the pathogenesis of metabolic diseases will be beneficial to reveal the complex network regulation mechanism of metabolic diseases and provide new strategies for disease prevention and treatment.
This Research Topic aims to explore the bile acid and related metabolites and hormone abnormalities in the development of metabolic diseases, including 1, To reveal the role of bile acid, amino acids, lipids, and other metabolites in type 2 diabetes mellitus, nonalcoholic fatty liver disease and polycystic ovary syndrome and the molecular mechanism; 2. To identify the role and mechanism of abnormal hormones such as insulin, growth hormone and sex hormone in metabolic diseases; 3. To elucidate the new mechanism of the interaction between metabolites and hormones involved in the occurrence and development of metabolic diseases; 4. To find new targets for the prevention and treatment of metabolic diseases from the perspective of metabolites and hormones.
This Research Topic will accept manuscripts including, but not limited to the following:
• Bile acid, amino acids, lipids, and other metabolites in type 2 diabetes mellitus, nonalcoholic fatty liver disease and polycystic ovary syndrome
• Abnormal hormones such as insulin, growth hormone and sex hormone in metabolic diseases
• Interaction between metabolites and hormones in metabolic diseases
• New targets for the prevention and treatment of metabolic diseases from the perspective of metabolites and hormones
Abnormal metabolites and hormones play an important role in the pathogenesis of metabolic diseases such as type 2 diabetes, nonalcoholic fatty liver disease and polycystic ovary syndrome. Gut microbiota and its related metabolites such as bile acids, amino acids and lipids regulate the occurrence and development of metabolic diseases by directly acting on target organs or affecting the immune system and hormone homeostasis. There is a complex interaction between hormones (insulin, growth hormone, and sex hormone) and metabolites such as glucose, lipid and amino acid. The regulatory effect of bile acid and other metabolites and hormone abnormalities on metabolic diseases is still unclear. An in-depth investigation of the homeostasis regulation of metabolites and hormones and their interaction on the pathogenesis of metabolic diseases will be beneficial to reveal the complex network regulation mechanism of metabolic diseases and provide new strategies for disease prevention and treatment.
This Research Topic aims to explore the bile acid and related metabolites and hormone abnormalities in the development of metabolic diseases, including 1, To reveal the role of bile acid, amino acids, lipids, and other metabolites in type 2 diabetes mellitus, nonalcoholic fatty liver disease and polycystic ovary syndrome and the molecular mechanism; 2. To identify the role and mechanism of abnormal hormones such as insulin, growth hormone and sex hormone in metabolic diseases; 3. To elucidate the new mechanism of the interaction between metabolites and hormones involved in the occurrence and development of metabolic diseases; 4. To find new targets for the prevention and treatment of metabolic diseases from the perspective of metabolites and hormones.
This Research Topic will accept manuscripts including, but not limited to the following:
• Bile acid, amino acids, lipids, and other metabolites in type 2 diabetes mellitus, nonalcoholic fatty liver disease and polycystic ovary syndrome
• Abnormal hormones such as insulin, growth hormone and sex hormone in metabolic diseases
• Interaction between metabolites and hormones in metabolic diseases
• New targets for the prevention and treatment of metabolic diseases from the perspective of metabolites and hormones